Evidence map›Paper›PMID 31000786›Full record

ArticleBritish journal of cancer2019

LGR5 expression predicts peritoneal recurrence after curative resection of primary colon cancer.

Hiroshi Nagata, Soichiro Ishihara, Hiroyuki Abe, Tetsuo Ushiku, Junko Kishikawa, Toshiaki Tanaka, Keisuke Hata, Kazushige Kawai, Masashi Fukayama, Hiroaki Nozawa

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Hiroshi NagataDepartment of Surgical Oncology, The University of Tokyo, Tokyo, Japan. hinagata-tky@umin.ac.jp.ORCID http://orcid.org/0000-0003-0902-9208
Soichiro IshiharaDepartment of Surgical Oncology, The University of Tokyo, Tokyo, Japan.
Hiroyuki AbeDepartment of Pathology, The University of Tokyo, Tokyo, Japan.
Tetsuo UshikuDepartment of Pathology, The University of Tokyo, Tokyo, Japan.
Junko KishikawaDepartment of Surgical Oncology, The University of Tokyo, Tokyo, Japan.
Toshiaki TanakaDepartment of Surgical Oncology, The University of Tokyo, Tokyo, Japan.
Keisuke HataDepartment of Surgical Oncology, The University of Tokyo, Tokyo, Japan.
Kazushige KawaiDepartment of Surgical Oncology, The University of Tokyo, Tokyo, Japan.
Masashi FukayamaDepartment of Pathology, The University of Tokyo, Tokyo, Japan.
Hiroaki NozawaDepartment of Surgical Oncology, The University of Tokyo, Tokyo, Japan.
The University of Tokyo · JPUniversity of Tokyo Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of this study was to clarify whether a cancer stem cell marker could be an indicator of post-operative peritoneal recurrence of colon cancer.

methodsExpression of four putative markers (CD133, CD44 variant 6, aldehyde dehydrogenase-1 and leucine-rich repeating G-protein-coupled receptor-5 (LGR5)) was evaluated immunohistochemically in primary tumour samples from 292 patients who underwent curative resection for non-metastasised pT4 colon cancer at the University of Tokyo Hospital between 1997 and 2015.

resultsPeritoneal recurrence was significantly higher in LGR5-negative cases (5-year cumulative incidence: 27.5% vs. 14.4%, p = 0.037). Multivariable analysis confirmed that negative LGR5 expression was an independent risk factor for peritoneal recurrence (hazard ratio (HR) 2.79, p = 0.005) in addition to poor differentiation, positive lymph node metastasis, preoperative carcinoembryonic antigen > 5 ng/mL and anastomotic leakage. The addition of LGR5 significantly improved the predictive value of the multivariable model (net reclassification improvement: 0.186, p = 0.028: integrated discrimination improvement: 0.047, p = 0.008).

conclusionsNegative LGR5 expression was a significant predictor of peritoneal recurrence in patients with pT4 colon cancer. Therefore, LGR5 might be a promising biomarker to identify patients at high risk of post-operative peritoneal metastasis.

Indexed as

PrognosisAC133 AntigenAgedBiomarkers, TumorCarcinoembryonic AntigenColonic NeoplasmsFemaleGene Expression Regulation, NeoplasticGPI-Linked ProteinsHumansLymphatic MetastasisMaleMiddle AgedNeoplasm Recurrence, LocalNeoplasm StagingNeoplastic Stem CellsAC133 AntigenBiomarkers, TumorCarcinoembryonic AntigenCEACAM5 protein, humanGPI-Linked ProteinsLGR5 protein, humanReceptors, G-Protein-Coupled

Identifiers

PMID31000786
PMCPMC6734652
OpenAlexW2936160433

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.