ArticleScientific reports2019
Whole Genome Sequencing of Extended Spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae Isolated from Hospitalized Patients in KwaZulu-Natal, South Africa.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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46 citing papers in PubMed, 64 citations in OpenAlex.
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- Antimicrobial resistance, virulence defects, and evolutionary dynamics of multidrug-resistantMicrobiology spectrum · 2026Article
- Epidemiology of ESBL-Producing, Carbapenem-Resistant, and Carbapenemase-Producing Enterobacterales in Southern Africa.Antibiotics (Basel, Switzerland) · 2026Review
- Evaluation of plant-based antimicrobials in controlling antimicrobial resistance gene spread in poultry production continuum.Frontiers in veterinary science · 2026Article
- Systematic review on genomic insights into antimicrobial resistance in ESKAPE pathogens.African journal of laboratory medicine · 2026Review
- Whole genome sequencing of a hypermucoviscous, multidrug-resistant Klebsiella pneumoniae subsp. pneumoniae K219 isolated from human sputum.Scientific reports · 2025Article
- Plasmid-mediated quinolone resistance among extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolated from hospitalized patients, hospital environment and wastewaters in Cameroon.Scientific reports · 2025Article
- Comprehensive Genomic Characterization of a Drug-ResistantIranian journal of medical sciences · 2025Article
- Whole-Genome Sequencing and Bioinformatics Analysis of ESBL- producing Klebsiella pneumoniae in a Ghanaian teaching hospital.BMC microbiology · 2025Article
- Drug resistant Klebsiella pneumoniae from patients and hospital effluent: a correlation?BMC microbiology · 2025Article
- Insights into Molecular Profiles, Resistance Patterns, and Virulence Traits of Staphylococci from Companion Dogs in Angola.Animals : an open access journal from MDPI · 2025Article
- Whole-genome sequencing of extended spectrum beta lactamases (ESBLs)-producing Klebsiella pneumoniae (kp) isolates from selected hospitals in Malaysia.BMC genomics · 2025Article
- Genome Analysis of 6222 Bacterial Isolates from Livestock and Food Environments in Spain to Decipher the Antibiotic Resistome.Antibiotics (Basel, Switzerland) · 2025Article
- Mechanisms of Antimicrobial Resistance inInfection and drug resistance · 2025Review
- Review
- First report of carbapenems encoding multidrug-resistant gram-negative bacteria from a pediatric hospital in Gaza Strip, Palestine.BMC microbiology · 2024Article
- Antimicrobial resistance and prevalence of extended-spectrum beta-lactamase-producingMicrobiology spectrum · 2024Article
- Molecular Characterization of Carbapenem and Colistin Resistance inMicroorganisms · 2024Article
- Pathogenomics analysis of high-risk clone ST147 multidrug-resistant Klebsiella pneumoniae isolated from a patient in Egypt.BMC microbiology · 2024Article
- The importance of "one health approach" to the AMR study and surveillance in Angola and other African countries.One health (Amsterdam, Netherlands) · 2024Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extended spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae remain a critical clinical concern worldwide. The aim of this study was to characterize ESBL-producing K. pneumoniae detected within and between two hospitals in uMgungundlovu district, South Africa, using whole genome sequencing (WGS). An observational period prevalence study on antibiotic-resistant ESKAPE (i.e. Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp.) bacteria was carried out in hospitalized patients during a two-month period in 2017. Rectal swabs and clinical specimens were collected from patients hospitalized and were screened for ESBL-producing, Gram-negative ESKAPE bacteria using cefotaxime-containing MacConkey agar and ESBL combination disk tests. Nine confirmed ESBL-K. pneumoniae isolated from six patients and two hospitals were whole genome sequenced using an Illumina MiSeq platform. Genome sequences were screened for presence of integrons, insertion sequences, plasmid replicons, CRISPR regions, resistance genes and virulence genes using different software tools. Of the 159 resistant Gram-negative isolates collected, 31 (19.50%) were ESBL-producers, of which, nine (29.03%) were ESBL-K. pneumoniae. The nine K. pneumoniae isolates harboured several β-lactamase genes, including bla
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