Evidence map›Paper›PMID 31000683›Full record

ArticleThe Journal of experimental medicine2019

Oncogenic kinase inhibition limits Batf3-dependent dendritic cell development and antitumor immunity.

Benjamin D Medina, Mengyuan Liu, Gerardo A Vitiello, Adrian M Seifert, Shan Zeng, Timothy Bowler, Jennifer Q Zhang, Michael J Cavnar, Jennifer K Loo, Nesteene J Param and 4 more

Abstract read
In one paragraph

Article in The Journal of experimental medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Benjamin D MedinaDepartment of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY.ORCID 0000-0002-4776-779X
Mengyuan LiuDepartment of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY.ORCID 0000-0002-6415-9788
Gerardo A VitielloDepartment of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY.ORCID 0000-0002-7452-8903
Adrian M SeifertDepartment of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY.ORCID 0000-0002-5329-3164
Shan ZengDepartment of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY.
Timothy BowlerDepartment of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY.
Jennifer Q ZhangDepartment of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY.
Michael J CavnarDepartment of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY.ORCID 0000-0002-6197-7945
Jennifer K LooDepartment of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY.
Nesteene J ParamDepartment of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY.
Joanna H MaltbaekDepartment of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY.ORCID 0000-0003-3225-1843
Ferdinand RossiDepartment of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY.
Vinod BalachandranDepartment of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY.
Ronald P DeMatteoDepartment of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY ronald.dematteo@uphs.upenn.edu.ORCID 0000-0002-7021-8852
Memorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Molecular Mechanisms in Gastrointestinal Stromal TumorR01CA102613 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Ronald P. Dematteo · 2004 to 2026
$9.2M
SURGICAL ONCOLOGY RESEARCH TRAINING PROGRAMT32CA009501 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Babak J Mehrara · 1985 to 2026
$7.7M
Tyrosine kinase inhibition and immunomodulation for cancerF32CA186534 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI ZHANG, JENNIFER Q · 2014 to 2015
$109k
NCATS NIH HHS L30 TR002111NCI NIH HHS F32 CA186534NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA102613NCI NIH HHS T32 CA009501
6 · The paper itself

Abstract

Gastrointestinal stromal tumor (GIST) is driven by an activating mutation in the

Indexed as

ImmunityAnimalsAntigens, CDBasic-Leucine Zipper Transcription FactorsCarcinogenesisCD8-Positive T-LymphocytesCell DifferentiationChemotactic FactorsDendritic CellsGastrointestinal Stromal TumorsGranulocyte-Macrophage Colony-Stimulating FactorImatinib MesylateImmunologic MemoryMacrophagesMice, Inbred C57BLMonitoring, ImmunologicAntigens, CDBasic-Leucine Zipper Transcription FactorsBATF3 protein, humanChemotactic FactorsGranulocyte-Macrophage Colony-Stimulating FactorImatinib MesylateMAS1 protein, humanProtein Kinase InhibitorsProto-Oncogene MasReceptors, Antigen, T-Cell, gamma-deltaRepressor ProteinsSNFT protein, mouse

Identifiers

PMID31000683
PMCPMC6547861
OpenAlexW2937470558

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.