ArticleScience (New York, N.Y.)2019
Amygdala ensembles encode behavioral states.
Article in Science (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers, 1 of them a synthesis that pooled it.
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Who cites it
120 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Hemispheric Asymmetries in Bipolar Disorder: A Systematic Review.Medicina (Kaunas, Lithuania) · 2026Pooled it
- Article
- An amygdala-mediated simulation-to-decision cascade aligns interbrain dynamics to solve social dilemmas.Nature neuroscience · 2026Article
- Human claustrum neurons encode uncertainty and prediction errors during aversive learning.Nature neuroscience · 2026Article
- Cannabinoid modulation of central amygdala population dynamics during threat investigation.Nature communications · 2026Article
- Complementary stable and dynamic prelimbic ensembles encode learned threat value underlying generalization and discrimination.bioRxiv : the preprint server for biology · 2026Article
- Functional specialization of mPFC-BLA and mPFC-NAc pathways in affective state representation.eLife · 2026Article
- Uncovering internal states with a robust shared-state multi-neuron GLM-HMM framework.bioRxiv : the preprint server for biology · 2026Article
- The representational geometry of emotional states in basolateral amygdala.Nature neuroscience · 2026Article
- Oxytocin selectively biases sensory-prefrontal communication through network-level suppression and theta coupling.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Basolateral amygdala dopamine transmits emotional salience.Nature communications · 2026Article
- Sex-specific behavioral feedback modulates sensorimotor processing and drives flexible social behavior.Nature communications · 2026Article
- Sensory and palatability coding of taste stimuli in cortex involves dynamic and asymmetric cortico-amygdalar interactions.Journal of neurophysiology · 2026Article
- Neural representation of emotional valence in human amygdala and surrounding regions.NeuroImage · 2026Article
- Reliable Inference of the Encoding of Task States by Individual Neurons Using Calcium Imaging.eNeuro · 2026Article
- Identifying the factors governing internal state switches during nonstationary sensory decision-making.Nature communications · 2025Article
- Integrating Aversive Memories in the Basolateral Amygdala.Biological psychiatry · 2025Review
- Heterogeneous plasticity of amygdala interneurons in associative learning and extinction.Nature communications · 2025Article
- Synaptic organization and associative learning-related activity of basolateral amygdala interneurons.Cell reports · 2025Article
- Risk reshapes amygdala representation of choice.bioRxiv : the preprint server for biology · 2025Article
60 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Internal states, including affective or homeostatic states, are important behavioral motivators. The amygdala regulates motivated behaviors, yet how distinct states are represented in amygdala circuits is unknown. By longitudinally imaging neural calcium dynamics in freely moving mice across different environments, we identified opponent changes in activity levels of two major, nonoverlapping populations of basal amygdala principal neurons. This population signature does not report global anxiety but predicts switches between exploratory and nonexploratory, defensive states. Moreover, the amygdala separately processes external stimuli and internal states and broadcasts state information via several output pathways to larger brain networks. Our findings extend the concept of thalamocortical "brain-state" coding to include affective and exploratory states and provide an entry point into the state dependency of brain function and behavior in defined circuits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.