Evidence map›Paper›PMID 31000594›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Topological descriptions of protein folding.

Erica Flapan, Adam He, Helen Wong

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Energy Landscapes of Model Knotted Polymers.Journal of chemical theory and computation · 2025
    Article
  3. Folds from fold: Exploring topological isoforms of a single-domain protein.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  4. Article
  5. Article
  6. Computing a Link Diagram From Its Exterior.Discrete & computational geometry · 2024
    Article
  7. Energy spectrum of the ideal DNA knot on a torus.European biophysics journal : EBJ · 2023
    Article
  8. Article
  9. Are there double knots in proteins? Prediction andFrontiers in molecular biosciences · 2023
    Article
  10. Article
  11. A reappraisal of the form - function problem. Theory and phenomenology.Theory in biosciences = Theorie in den Biowissenschaften · 2022
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Erica FlapanDepartment of Mathematics, Pomona College, Claremont, CA 91711.
Adam HeComputational Biology Program, Cornell University, Ithaca, NY 14853.ORCID 0000-0003-2084-6970
Helen WongDepartment of Mathematical Sciences, Claremont McKenna College, Claremont, CA 91711 hwong@cmc.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

How knotted proteins fold has remained controversial since the identification of deeply knotted proteins nearly two decades ago. Both computational and experimental approaches have been used to investigate protein knot formation. Motivated by the computer simulations of Bölinger et al. [Bölinger D, et al. (2010)

Indexed as

Computer SimulationDatabases, ProteinProtein ConformationProtein FoldingProteinsProteinsknot foldingprotein knotsprotein topology

Identifiers

PMID31000594
PMCPMC6510998

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.