ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019
White Matter Microstructure Reflects Individual Differences in Music Reward Sensitivity.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05505019 (The Role of a Personalized Music Intervention Towards Alleviating Apathy in Parkinson's Disease), which is not on this map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Role of a Personalized Music Intervention Towards Alleviating Apathy in Parkinson's Disease
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- White matter variability, cognition, and disorders: a systematic review.Brain structure & function · 2022Pooled it
- When Music Loses Its Pleasure: Hippocampal Cingulum White Matter as a Structural Mediator of Musical Reward Decline in Aging.bioRxiv : the preprint server for biology · 2026Article
- The relationship between individual sensitivity to music reward and rhythmic processing.Psychological research · 2026Article
- Music reward sensitivity and subjective well-being in college students: the indirect pathways of resilience and perceived social support.Frontiers in psychology · 2026Article
- Predicting artificial neural network representations to learn recognition model for music identification from brain recordings.Scientific reports · 2025Article
- Twin modelling reveals partly distinct genetic pathways to music enjoyment.Nature communications · 2025Article
- Music-Evoked Nostalgia Activates Default Mode and Reward Networks Across the Lifespan.Human brain mapping · 2025Article
- Enriched Exercise Environment Boosting Exercise Effects on the Brain: Beneficial Effects of Music.Advances in neurobiology · 2025Review
- Article
- Microstructure of the cerebellum and its afferent pathways underpins dystonia in myoclonus dystonia.European journal of neurology · 2024Article
- Music reward sensitivity is associated with greater information transfer capacity within dorsal and motor white matter networks in musicians.Brain structure & function · 2024Article
- Modality-specific and modality-general representations of subjective value in frontal cortex.Communications biology · 2024Article
- Neural Mechanism of Musical Pleasure Induced by Prediction Errors: An EEG Study.Brain sciences · 2024Article
- State-dependent connectivity in auditory-reward networks predicts peak pleasure experiences to music.PLoS biology · 2024Article
- Article
- Uncovering sympathetic nervous system dysfunction in disorders of consciousness via heart rate variability during head-up tilt test.Physiological reports · 2024Article
- Musical anhedonia, timbre, and the rewards of music listening.Cognition · 2024Article
- Modelling individual aesthetic judgements over time.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Generating New Musical Preferences From Multilevel Mapping of Predictions to Reward.Psychological science · 2024Article
- Predictive coding in musical anhedonia: A study of groove.PloS one · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
People show considerable variability in the degree of pleasure they experience from music. These individual differences in music reward sensitivity are driven by variability in functional connectivity between the nucleus accumbens (NAcc), a key structure of the reward system, and the right superior temporal gyrus (STG). However, it is unknown whether a neuroanatomical basis exists for this variability. We used diffusion tensor imaging and probabilistic tractography to study the relationship between music reward sensitivity and white matter microstructure connecting these two regions via the orbitofrontal cortex (OFC) in 38 healthy human participants (24 females and 14 males). We found that right axial diffusivity (AD) in the STG-OFC connectivity inversely correlated with music reward sensitivity. Additionally, right mean diffusivity and left AD in the NAcc-OFC tract also showed an inverse correlation. Further, AD in this tract also correlated with previously acquired BOLD activity during music listening, but not for a control monetary reward task in the NAcc. Finally, we used mediation analysis to show that AD in the NAcc-OFC tract explains the influence of NAcc activation during a music task on music reward sensitivity. Overall, our results provide further support for the idea that the exchange of information among perceptual, integrative, and reward systems is important for musical pleasure, and that individual differences in the structure of the relevant anatomical connectivity influences the degree to which people are able to derive such pleasure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.