Evidence map›Paper›PMID 31000586›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019

HDAC3-Mediated Repression of the

Janine L Kwapis, Yasaman Alaghband, Alberto J López, Jeffrey M Long, Xiang Li, Guanhua Shu, Kasuni K Bodinayake, Dina P Matheos, Peter R Rapp, Marcelo A Wood

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 63 citations in OpenAlex.

  1. Article
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  4. CD4Combinatorial chemistry & high throughput screening · 2026
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  9. Regulation ofInternational journal of molecular sciences · 2025
    Review
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  11. Review
  12. Review
  13. Enhancement of physiology via adaptive transcription.Pflugers Archiv : European journal of physiology · 2025
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Progressive reduction of nuclear receptor Nr4a1 mediates age-dependent cognitive decline.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  19. Article
  20. Inhibition ofeLife · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Janine L KwapisDepartment of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, California 92697, and.ORCID 0000-0002-2349-8601
Yasaman AlaghbandDepartment of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, California 92697, and.
Alberto J LópezDepartment of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, California 92697, and.
Jeffrey M LongLaboratory of Behavioral Neuroscience, National Institute on Aging, Biomedical Research Center, National Institutes of Health, Baltimore, Maryland 21224.
Xiang LiDepartment of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, California 92697, and.
Guanhua ShuDepartment of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, California 92697, and.
Kasuni K BodinayakeDepartment of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, California 92697, and.
Dina P MatheosDepartment of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, California 92697, and.
Peter R RappLaboratory of Behavioral Neuroscience, National Institute on Aging, Biomedical Research Center, National Institutes of Health, Baltimore, Maryland 21224.ORCID 0000-0002-0983-3944
Marcelo A WoodDepartment of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, California 92697, and mwood@uci.edu.
University of California, Irvine · USNational Institutes of Health · US

Funding

Neurocognitive Aging: Experience-Dependent Dynamics, Plasticity and Network ContributionsZIAAG000350 · NIA · NATIONAL INSTITUTE ON AGING · PI RAPP, PETER R · 2009 to 2025
$30.9M
Exercise-induced epigenetic mechanisms underlying neuronal plasticity and cognitionR01AG051807 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI COTMAN, CARL WAYNE, WOOD, MARCELO ANDRES · 2016 to 2020
$3.1M
Role of Neuron-Specific Nucleosome Remodeling in Intellectual DisabilityR01MH101491 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI LYNCH, GARY S, WOOD, MARCELO ANDRES · 2013 to 2017
$2.3M
Role of HDAC3 in repressing memory formation in the aging brainR21AG050787 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI WOOD, MARCELO ANDRES · 2016 to 2017
$425k
Role of a medial habenula circuit and Nr4a2 in regulating cocaine action during reinstatementK00DA048436 · NIDA · VANDERBILT UNIVERSITY · PI LOPEZ, ALBERTO J · 2018 to 2021
$253k
Epigenetic regulation of the circadian gene Per1 in age-related memory impairmentsK99AG056596 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI KWAPIS, JANINE LYNN · 2017 to 2018
$201k
Epigenetic repression of synaptic plasticity and memory in the aging brainF32AG052303 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI KWAPIS, JANINE LYNN · 2015 to 2017
$88k
Role of a medial habenula circuit and Nr4a2 in regulating cocaine action during reinstatementF99NS105217 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI LOPEZ, ALBERTO J · 2017 to 2017
$39k
NIA NIH HHS F32 AG052303NIA NIH HHS K99 AG056596NIA NIH HHS R01 AG051807NIA NIH HHS R21 AG050787NIMH NIH HHS R01 MH101491NINDS NIH HHS F99 NS105217
6 · The paper itself

Abstract

Aging is accompanied by cognitive deficits, including impairments in long-term memory formation. Understanding the molecular mechanisms that support preserved cognitive function in aged animals is a critical step toward identifying novel therapeutic targets that could improve memory in aging individuals. One potential mechanism is the

Indexed as

AgingAnimalsDisease Models, AnimalGene Expression RegulationHistone Deacetylase 3Histone DeacetylasesMemory DisordersMemory, Long-TermNuclear Receptor Subfamily 4, Group A, Member 1Nuclear Receptor Subfamily 4, Group A, Member 2RatsHistone Deacetylase 3Histone DeacetylasesNr4a1 protein, ratNr4a2 protein, ratNuclear Receptor Subfamily 4, Group A, Member 1Nuclear Receptor Subfamily 4, Group A, Member 2agingepigeneticsHDAC3memoryNr4a1Nr4a2

Identifiers

PMID31000586
PMCPMC6670247
OpenAlexW2940236756

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.