Evidence map›Paper›PMID 31000521›Full record

ArticleGenetics2019

Overlapping Roles in Chromosome Segregation for Heterochromatin Protein 1 (Swi6) and DDK in

Kuo-Fang Shen, Susan L Forsburg

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Kuo-Fang ShenProgram in Molecular and Computational Biology, University of Southern California, Los Angeles, California 90089-2910.ORCID 0000-0002-6691-8194
Susan L ForsburgProgram in Molecular and Computational Biology, University of Southern California, Los Angeles, California 90089-2910 Forsburg@usc.edu.ORCID 0000-0002-4895-8598
University of Southern California · US

Funding

Mechanisms linking replication stress to genome instability in fission yeastR35GM118109 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI FORSBURG, SUSAN L · 2016 to 2025
$7.1M
NIGMS NIH HHS R35 GM118109
6 · The paper itself

Abstract

Fission yeast Swi6 is a human HP1 homolog that plays important roles in multiple cellular processes. In addition to its role in maintaining heterochromatin silencing, Swi6 is required for cohesin enrichment at the pericentromere. Loss of Swi6 leads to abnormal mitosis, including defects in the establishment of bioriented sister kinetochores and microtubule attachment. Swi6 interacts with Dfp1, a regulatory subunit of DBF4-dependent kinase (DDK), and failure to recruit Dfp1 to the pericentromere results in late DNA replication. Using the

Indexed as

Cell Cycle ProteinsCentromereChromobox Protein Homolog 5Chromosomal Proteins, Non-HistoneChromosome SegregationCohesinsDNA ReplicationKinetochoresMitosisProtein KinasesProtein Serine-Threonine KinasesRepressor ProteinsSchizosaccharomycesSchizosaccharomyces pombe ProteinsCell Cycle ProteinsCHP2 protein, S pombeChromobox Protein Homolog 5Chromosomal Proteins, Non-HistoneCohesinsDDK protein, S pombeDfp1 protein, S pombeProtein KinasesProtein Serine-Threonine KinasesRad21 protein, S pombeRepressor ProteinsSchizosaccharomyces pombe ProteinsSwi6 protein, S pombeCdc7/Hsk1Chp1 and SACCnp1fission yeastheterochromatinkinetochoreminichromosomemitosis

Identifiers

PMID31000521
PMCPMC6553818
OpenAlexW2940117868

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.