Evidence map›Paper›PMID 31000096›Full record

ArticleJACC. Clinical electrophysiology2019

Localization of Accessory Pathways in Pediatric Patients With Wolff-Parkinson-White Syndrome Using 3D-Rendered Electromechanical Wave Imaging.

Lea Melki, Christopher S Grubb, Rachel Weber, Pierre Nauleau, Hasan Garan, Elaine Wan, Eric S Silver, Leonardo Liberman, Elisa E Konofagou

Open access · greenAbstract read
In one paragraph

Article in JACC. Clinical electrophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

  1. Electromechanical wave imaging vs electrocardiographic imaging: a direct comparison of non-invasive ventricular activation mapping modalities.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Cardiac Resynchronization Therapy Response Assessment with Electromechanical Activation Mapping within 24 Hours of Device Implantation: A Pilot Study.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2021
    Article
  6. Article
  7. 4D cardiac electromechanical activation imaging.Computers in biology and medicine · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Lea MelkiUltrasound Elasticity Imaging Laboratory, Department of Biomedical Engineering, Columbia University, New York, New York.
Christopher S GrubbDivision of Cardiology, Department of Medicine, Columbia University Medical Center, New York, New York.
Rachel WeberUltrasound Elasticity Imaging Laboratory, Department of Biomedical Engineering, Columbia University, New York, New York.
Pierre NauleauUltrasound Elasticity Imaging Laboratory, Department of Biomedical Engineering, Columbia University, New York, New York.
Hasan GaranDivision of Cardiology, Department of Medicine, Columbia University Medical Center, New York, New York.
Elaine WanDivision of Cardiology, Department of Medicine, Columbia University Medical Center, New York, New York.
Eric S SilverPediatric Electrophysiology, Division of Pediatric Cardiology, Department of Pediatrics, Columbia University Medical Center, New York, New York.
Leonardo LibermanPediatric Electrophysiology, Division of Pediatric Cardiology, Department of Pediatrics, Columbia University Medical Center, New York, New York.
Elisa E KonofagouUltrasound Elasticity Imaging Laboratory, Department of Biomedical Engineering, Columbia University, New York, New York; Department of Radiology, Columbia University Medical Center, New York, New York. Electronic address: ek2191@columbia.edu.
Columbia University Irving Medical Center · USColumbia University · US

Funding

Arrhythmia mapping using electromechanical wave imagingR01HL140646 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Elisa E. Konofagou · 2018 to 2026
$5.6M
EARLY DETECTION AND MAPPING OF ISCHEMIA USING MYOCARDIAL ELASTOGRAPHYR01EB006042 · NIBIB · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI KONOFAGOU, ELISA E. · 2006 to 2018
$4.3M
Noninvasive arrhythmia mapping using Electromechanical Wave ImagingR01HL114358 · NHLBI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI KONOFAGOU, ELISA E. · 2012 to 2016
$1.9M
Role of Vascular Ion Channels in Heart Failure and Cardiovascular DiseasesK08HL122526 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WAN, ELAINE Y · 2015 to 2019
$788k
NHLBI NIH HHS K08 HL122526NHLBI NIH HHS R01 HL114358NHLBI NIH HHS R01 HL140646NIBIB NIH HHS R01 EB006042
6 · The paper itself

Abstract

objectivesThis study sought to demonstrate the feasibility of electromechanical wave imaging (EWI) for localization of accessory pathways (AP) prior to catheter ablation in a pediatric population.

backgroundPrediction of AP locations in patients with Wolff-Parkinson-White syndrome is currently based on analysis of 12-lead electrocardiography (ECG). In the pediatric population, specific algorithms have been developed to aid in localization, but these can be unreliable. EWI is a noninvasive imaging modality relying on a high frame rate ultrasound sequence capable of visualizing cardiac electromechanical activation.

methodsPediatric patients with ventricular pre-excitation presenting for catheter ablation were imaged with EWI immediately prior to the start of the procedure. Two clinical pediatric electrophysiologists predicted the location of the AP based on ECG. Both EWI and ECG predictions were blinded to the results of catheter ablation. EWI and ECG localizations were subsequently compared with the site of successful ablation.

resultsFifteen patients were imaged with EWI. One patient was excluded for poor echocardiographic windows and the inability to image the entire ventricular myocardium. EWI correctly predicted the location of the AP in all 14 patients. ECG analysis correctly predicted 11 of 14 (78.6%) of the AP locations.

conclusionsEWI was shown to be capable of consistently localizing accessory pathways. EWI predicted the site of successful ablation more frequently than analysis of 12-lead ECG. EWI isochrones also provide anatomical visualization of ventricular pre-excitation. These findings suggest that EWI can predict AP locations, and EWI may have the potential to better inform clinical electrophysiologists prior to catheter ablation procedures.

Indexed as

Accessory Atrioventricular BundleAdolescentAlgorithmsCardiac Imaging TechniquesCatheter AblationChildElectrocardiographyElectromagnetic RadiationFeasibility StudiesFemaleHumansImaging, Three-DimensionalMaleWolff-Parkinson-White Syndromeaccessory pathwaycatheter ablationechocardiographytreatment planningultrasoundWolff-Parkinson-White

Identifiers

PMID31000096
PMCPMC6478397
OpenAlexW2911767597

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.