Evidence map›Paper›PMID 30999973›Full record

ReviewCurrent topics in developmental biology2019

Genetic regulation of sex determination and maintenance in zebrafish (Danio rerio).

Michelle E Kossack, Bruce W Draper

Open access · greenAbstract readReview
In one paragraph

Review in Current topics in developmental biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers.

0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed
44.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

89 citing papers in PubMed, 167 citations in OpenAlex.

  1. Article
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  9. Consequences of Cancer on ZebrafishEcology and evolution · 2025
    Article
  10. Article
  11. Regulation of early gonocyte differentiation in zebrafish.Biochemical Society transactions · 2025
    Article
  12. Article
  13. Review
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  18. Review
  19. Article
  20. Article

29 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Michelle E KossackMolecular and Cellular Biology, University of California, Davis, CA, United States.
Bruce W DraperMolecular and Cellular Biology, University of California, Davis, CA, United States. Electronic address: bwdraper@ucdavis.edu.
University of California, Davis · US

Funding

ENVIRONMENTAL TOXICOLOGYT32ES007059 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI Laura S Van Winkle · 1985 to 2026
$7.9M
NIEHS NIH HHS T32 ES007059
6 · The paper itself

Abstract

Over the last several decades zebrafish (Danio rerio) has become a major model organism for the study of vertebrate development and physiology. Given this, it may be surprising how little is known about the mechanism that zebrafish use to determine sex. While zebrafish are a gonochoristic species (having two sexes) that do not switch sex as adults, it was appreciated early on that sex ratios obtained from breeding lab domesticated lines were not typically a 1:1 ratio of male and female, suggesting that sex was not determined by a strict chromosomal mechanism. Here we will review the recent progress toward defining the genetic mechanism for sex determination in both wild and domesticated zebrafish.

Indexed as

AnimalsGene Expression Regulation, DevelopmentalSex Determination ProcessesSex DifferentiationZebrafishZebrafish ProteinsZebrafish ProteinsAndrogen receptorAnti-Müllerian hormoneAromataseBmp15Chromosomal sex determinationCyp19a1aDmrt1Environmental sex determinationFoxl2aFoxl2bGerm cellGsdfNr0b1OocytesSex determinationSex differentiationSex maintenanceSomatic gonadWnt4aZebrafish

Identifiers

PMID30999973
PMCPMC6894417
OpenAlexW2922730069

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.