ArticleBMC oral health2019
Impact of polyols on Oral microbiome of Estonian schoolchildren.
Article in BMC oral health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01062633 (Effect of Erythritol and Xylitol on Dental Caries Prevention in Children), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Erythritol and Xylitol on Dental Caries Prevention in Children
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Clinical Effects of Sugar Substitutes on Cariogenic Bacteria: A Systematic Review and Meta-Analysis.International dental journal · 2024Pooled it
- Effects of 4-week xylitol tablet intake on tongue microbiota composition in children: a single-arm pilot study.Microbiology spectrum · 2026Article
- Importance of human microbiome: an update.Frontiers in microbiomes · 2026Review
- Effects of a Novel Magnetic Nanomaterial on Oral Biofilms.International dental journal · 2025Article
- Human oral microbiome and its influence on mental health and brain disorders.AIMS microbiology · 2025Review
- Antimicrobial Activity of Honey against Oral Microorganisms: Current Reality, Methodological Challenges and Solutions.Microorganisms · 2022Review
- Obesity influences composition of salivary and fecal microbiota and impacts the interactions between bacterial taxa.Physiological reports · 2022Article
- The Oral Microbiota: Community Composition, Influencing Factors, Pathogenesis, and Interventions.Frontiers in microbiology · 2022Review
- Effect of erythritol and xylitol on Streptococcus pyogenes causing peritonsillar abscesses.Scientific reports · 2021Article
- The Biocompatibility of a New Erythritol-and Xyltol-Containing Fluoride Toothpaste.Healthcare (Basel, Switzerland) · 2021Article
- Phenotypic changes in group B streptococci grown in the presence of the polyols, erythritol, sorbitol and mannitol.BMC microbiology · 2021Article
- Optimizing the quality of clinical studies on oral microbiome: A practical guide for planning, performing, and reporting.Periodontology 2000 · 2021Review
- Article
- Article
- Microbial Etiology and Prevention of Dental Caries: Exploiting Natural Products to Inhibit Cariogenic Biofilms.Pathogens (Basel, Switzerland) · 2020Review
- Oral Microbiome of Children Living in an Isolated Area in Myanmar.International journal of environmental research and public health · 2020Article
- Article
- Neuroendocrine and Metabolic Effects of Low-Calorie and Non-Calorie Sweeteners.Frontiers in endocrinology · 2020Review
- Oral microbial biofilms: an update.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOral microbiome has significant impact on both oral and general health. Polyols have been promoted as sugar substitutes in prevention of oral diseases. We aimed to reveal the effect of candies containing erythritol, xylitol or control (sorbitol) on salivary microbiome.
methodsNinety children (11.3 ± 0.6 years) consumed candies during 3 years. Microbial communities were profiled using Illumina HiSeq 2000 sequencing and real-time PCR.
resultsThe dominant phyla in saliva were Firmicutes (39.1%), Proteobacteria (26.1%), Bacteroidetes (14.7%), Actinobacteria (12%) and Fusobacteria (6%). The microbiome of erythritol group significantly differed from that of the other groups. Both erythritol and xylitol reduced the number of observed bacterial phylotypes in comparison to the control group. The relative abundance of the genera Veillonella, Streptococcus and Fusobacterium were higher while that of Bergeyella lower after erythritol intervention when comparing with control. The lowest prevalence of caries-related mutans streptococci corresponded with the lowest clinical caries markers in the erythritol group.
conclusionsDaily consumption of erythritol, xylitol or control candies has a specific influence on the salivary microbiome composition in schoolchildren. Erythritol is associated with the lowest prevalence of caries-related mutans streptococci and the lowest levels of clinical caries experience.
trial registrationClinicalTrials.gov Identifier NCT01062633.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.