Evidence map›Paper›PMID 30999897›Full record

Trial reportJournal of the International Society of Sports Nutrition2019

The effects of TeaCrine® and caffeine on endurance and cognitive performance during a simulated match in high-level soccer players.

Marissa L Bello, Alan J Walker, Bridget A McFadden, David J Sanders, Shawn M Arent

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the International Society of Sports Nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05170113 (A Pilot, Randomized, Double-blind, Placebo-controlled, Parallel Design Study to Evaluate the Effectiveness and Safety of an Alpinia Galanga Formulation, Theacrine Formulation, and Caffeine Formulation on Fatigue, Mental Acuity, and Cognitive Health Among Overall Healthy Participants), which is not on this map. Cited by 27 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05170113 nacompletednot on this mapstarted 2021, after this paper: background citation

A Pilot, Randomized, Double-blind, Placebo-controlled, Parallel Design Study to Evaluate the Effectiveness and Safety of an Alpinia Galanga Formulation, Theacrine Formulation, and Caffeine Formulation on Fatigue, Mental Acuity, and Cognitive Health Among Overall Healthy Participants

TypeinterventionalSponsorSupplement Formulators, Inc.Ran2021 to 2022Enrolled79ConditionsFatigueArmsAlpinia galanga formulation, Theacrine formulation, Caffeine formulation, Placebo
3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  5. Theacrine as a novel ergogenic aid: impact on canoe sprint performance.Journal of the International Society of Sports Nutrition · 2025
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  11. Effects of Theacrine as a Pre-Workout Supplement.International journal of environmental research and public health · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Marissa L BelloIFNH Center for Health and Human Performance, Rutgers University, 61 Dudley Rd, New Brunswick, NJ, 08901, USA.
Alan J WalkerIFNH Center for Health and Human Performance, Rutgers University, 61 Dudley Rd, New Brunswick, NJ, 08901, USA.
Bridget A McFaddenIFNH Center for Health and Human Performance, Rutgers University, 61 Dudley Rd, New Brunswick, NJ, 08901, USA.
David J SandersIFNH Center for Health and Human Performance, Rutgers University, 61 Dudley Rd, New Brunswick, NJ, 08901, USA.
Shawn M ArentIFNH Center for Health and Human Performance, Rutgers University, 61 Dudley Rd, New Brunswick, NJ, 08901, USA. shawn.arent@rutgers.edu.

Funding

Compound Solutions Inc. 103513
6 · The paper itself

Abstract

backgroundTheacrine (1,3,7,9-tetramethyluric-acid) is a pure alkaloid with a similar structure to caffeine and acts comparably as an adenosine receptor antagonist. Early studies have shown non-habituating effects, including increases in energy and focus in response to Teacrine®, the compound containing pure theacrine. The purpose of this study was to determine and compare the effects of Teacrine® and caffeine on cognitive performance and time-to-exhaustion during a simulated soccer game in high-level male and female athletes.

methodsMale and female soccer players (N = 24; M

resultsTTE trended towards significance in TeaCrine® and TeaCrine® + caffeine conditions compared to placebo (P < 0.052). A condition main effect (P < 0.05) occurred with faster CRT in caffeine and TeaCrine® + caffeine compared to placebo. COGRT

conclusionsThe 27-38% improvements in TTE reflect increased performance capacity that may have important implications for overtime scenarios. These findings suggest TeaCrine® favorably impacts endurance and the combination with caffeine provides greater benefits on cognitive function than either supplement independently.

Indexed as

Dietary SupplementsSoccerAdolescentAthletic PerformanceCaffeineCognitionDouble-Blind MethodExercise TestFemaleHumansMaleOxygen ConsumptionReaction TimeUric AcidYoung Adult1,3,7,9-tetramethyluric acidCaffeineUric AcidCaffeineCognitive functionEnduranceSoccerTheacrine

Identifiers

PMID30999897
PMCPMC6472067

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.