ArticleBMC nephrology2019
Associations of serum and dialysate electrolytes with QT interval and prolongation in incident hemodialysis: the Predictors of Arrhythmic and Cardiovascular Risk in End-Stage Renal Disease (PACE) study.
Article in BMC nephrology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Dynamic potassium variability (K-CV) as an independent predictor of mortality in maintenance hemodialysis.Renal failure · 2026Article
- Sex differences in the association between corrected serum calcium and sudden death in patients undergoing maintenance hemodialysis: ten-year outcomes of the Q-cohort study.Clinical and experimental nephrology · 2026Article
- Non-Invasive Monitoring of Hemodialysis Patients: Challenges and Benefits in the Real World.Clinics and practice · 2026Article
- Review
- Association of Electrocardiogram Abnormalities with Clinical Outcomes in Emergency Department Sepsis Patients.The western journal of emergency medicine · 2026Observational
- Risk factors and nomogram prediction model for hypocalcemia in patients undergoing hemodialysis.European journal of medical research · 2026Article
- Comparative effects of 1.25 vs. 1.5 mmol/L dialysate calcium concentrations on blood pressure variability during hemodialysis: a two-center retrospective study.Frontiers in medicine · 2026Article
- Exploring the association of natriuretic peptides with QTc interval in hemodialysis patients.Renal failure · 2025Article
- Relationship Between Timing of Hemodialysis and Procedure-Related Complications Following Endoscopy in Patients with End-Stage Renal Disease.Digestive diseases and sciences · 2025Article
- Association Between Disturbed Serum Phosphorus Levels and QT Interval Prolongation.Kidney international reports · 2024Article
- Characteristics, predictors and outcomes of new-onset QT prolongation in sepsis: a multicenter retrospective study.Critical care (London, England) · 2024Article
- Role of Chronic Kidney Disease (CKD)-Mineral and Bone Disorder (MBD) in the Pathogenesis of Cardiovascular Disease in CKD.Journal of atherosclerosis and thrombosis · 2023Review
- Prolongation of QTc interval at the beginning and during dialysis is associated with hypervolemia and calcium and magnesium change in the first 2 h.International urology and nephrology · 2022Article
- Monitoring of Serum Potassium and Calcium Levels in End-Stage Renal Disease Patients by ECG Depolarization Morphology Analysis.Sensors (Basel, Switzerland) · 2022Article
- Metabolic and electrolyte abnormalities as risk factors in drug-induced long QT syndrome.Biophysical reviews · 2022Review
- Association of abnormal electrocardiograph metrics with prolonged recovery time in incident hemodialysis patients.BMC nephrology · 2022Article
- The anti-aging factor Klotho protects against acquired long QT syndrome induced by uremia and promoted by fibroblast growth factor 23.BMC medicine · 2022Article
- Multitargeted interventions to reduce dialysis-induced systemic stress.Clinical kidney journal · 2021Review
- Electrolytes and clinical outcomes in patients with acute ischemic stroke or transient ischemic attack.Annals of translational medicine · 2021Article
- Effect of citric-acid dialysate on the QTC-interval.Scientific reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundProlonged QT interval in hemodialysis patients may be associated with sudden cardiac death, however, few studies examined the longitudinal associations of modifiable factors such as serum and dialysate concentrations of calcium, potassium, and magnesium with corrected QT (QTc) prolongation in incident hemodialysis patients.
methodsIn 330 in-center hemodialysis participants from the PACE study who were followed up for one year, we examined the associations of predialysis serum electrolytes (total calcium [Ca], corrected Ca [cCa], ionized Ca [iCa], potassium [K], magnesium [Mg]), dialysate (dCa and dK), and serum-to-dialysate gradient measures with QTc interval and prolongation (≥460 ms in women and ≥ 450 ms in men).
resultsAt the first study visit, 47% had QTc prolongation. Lower iCa and K were associated with longer QTc interval independent of potential confounders (QTc difference = 8.55[95% CI: 2.13, 14.97] ms for iCa; QTc difference = 9.89[1.58, 18.20] ms for K). Lower iCa was also associated with a higher risk of QTc prolongation. At 1 year of follow-up, 31% had persistent QTc prolongation. In longitudinal analyses, the associations of iCa and K with QTc interval remained significant, and lower K was associated with a higher risk of QTc prolongation while the association of iCa with QTc prolongation was borderline statistically significant. Serum Mg, dCa or dK, and respective gradients were not associated with QTc interval or prolongation.
conclusionProlonged QTc is very common in incident hemodialysis participants and persists over follow-up. Ionized Ca and K are consistently inversely associated with QTc prolongation, which suggests closer monitoring for a low calcium or potassium level to mitigate risk.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.