ArticleCells2019
MiR-34b-5p Mediates the Proliferation and Differentiation of Myoblasts by Targeting IGFBP2.
Article in Cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- Comparative transcriptome analysis reveals the coordinated regulation of the miR-34c-5p/AASS axis in chicken skeletal muscle development and intramuscular fat deposition.Food chemistry. Molecular sciences · 2026Article
- Tissue-specific roles of IGFBP2 in glucose and lipid metabolism in obesity-related metabolic diseases.Frontiers in nutrition · 2026Review
- Article
- Fasting Induces Gene Expression of Insulin-like Growth Factor-binding Proteins in Skeletal Muscles of Chicks.The journal of poultry science · 2025Article
- Identification and profiling of microRNAs during sheep's testicular development.Frontiers in veterinary science · 2025Article
- Effects of Amino Acid Supplementation to a Low-Protein Diet on the Growth Performance and Protein Metabolism-related Factors in Broiler Chicks.The journal of poultry science · 2024Article
- Article
- The miR151 and miR5100 Transfected Bone Marrow Stromal Cells Increase Myoblast Fusion in IGFBP2 Dependent Manner.Stem cell reviews and reports · 2022Article
- Differential expression profiles of miRNA in the serum of sarcopenic rats.Biochemistry and biophysics reports · 2022Article
- Identification and characterization of circular RNAs in Longissimus dorsi muscle tissue from two goat breeds using RNA-Seq.Molecular genetics and genomics : MGG · 2022Article
- MicroRNA-mRNA Regulatory Network Mediates Activation of mTOR and VEGF Signaling in African American Prostate Cancer.International journal of molecular sciences · 2022Article
- The Effect of Commercial Genetic Selection on Somatotropic Gene Expression in Broilers: A Potential Role for Insulin-Like Growth Factor Binding Proteins in Regulating Broiler Growth and Body Composition.Frontiers in physiology · 2022Article
- Nuclear Magnetic Resonance Therapy Modulates the miRNA Profile in Human Primary OA Chondrocytes and Antagonizes Inflammation in Tc28/2a Cells.International journal of molecular sciences · 2021Article
- MiRNAs and Muscle Regeneration: Therapeutic Targets in Duchenne Muscular Dystrophy.International journal of molecular sciences · 2021Review
- LncRNA-FKBP1C regulates muscle fiber type switching by affecting the stability of MYH1B.Cell death discovery · 2021Article
- Exploring biomarkers and therapeutic targets for pressure overload induced heart failure based on microarray data.Cardiovascular diagnosis and therapy · 2020Article
- Limb functional recovery is impaired in fibroblast growth factor-2 (FGF2) deficient mice despite chronic ischaemia-induced vascular growth.Growth factors (Chur, Switzerland) · 2020Article
- MiR-148a-3p Regulates Skeletal Muscle Satellite Cell Differentiation and Apoptosis via the PI3K/AKT Signaling Pathway by Targeting Meox2.Frontiers in genetics · 2020Article
- MiR-34b-5p inhibits cell proliferation, migration and invasion through targeting ARHGAP1 in breast cancer.American journal of translational research · 2020Article
- The Inhibition onCells · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As key post-transcriptional regulators, microRNAs (miRNAs) play an indispensable role in skeletal muscle development. Our previous study suggested that miR-34b-5p and IGFBP2 could have a potential role in skeletal muscle growth. Our goal in this study is to explore the function and regulatory mechanism of miR-34b-5p and IGFBP2 in myogenesis. In this study, the dual-luciferase reporter assay and Western blot analysis showed that IGFBP2 is a direct target of miR-34b-5p. Flow cytometric analysis and EdU assay showed that miR-34b-5p could repress the cell cycle progression of myoblasts, and miR-34b-5p could promote the formation of myotubes by promoting the expression of MyHC. On the contrary, the overexpression of IGFBP2 significantly facilitated the proliferation of myoblasts and hampered the formation of myotubes. Together, our results indicate that miR-34b-5p could mediate the proliferation and differentiation of myoblasts by targeting IGFBP2.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.