Evidence map›Paper›PMID 30999661›Full record

ReviewBiosensors2019

A Review on Surface-Enhanced Raman Scattering.

Roberto Pilot, Raffaella Signorini, Christian Durante, Laura Orian, Manjari Bhamidipati, Laura Fabris

Abstract readReview
In one paragraph

Review in Biosensors, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 244 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
244citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

244 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Metal/Si Nanowire Arrays for Hot Electron Catalysis.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Review
  18. Review
  19. SERS-Based Nano- and Microsystems Toward Biomedical Applications.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Review
  20. Article

184 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Roberto PilotDepartment of Chemical Sciences, University of Padova, 35131 Padova, Italy. roberto.pilot@unipd.it.
Raffaella SignoriniDepartment of Chemical Sciences, University of Padova, 35131 Padova, Italy. raffaella.signorini@unipd.it.
Christian DuranteDepartment of Chemical Sciences, University of Padova, 35131 Padova, Italy. christian.durante@unipd.it.
Laura OrianDepartment of Chemical Sciences, University of Padova, 35131 Padova, Italy. laura.orian@unipd.it.
Manjari BhamidipatiDepartment of Biomedical Engineering, Rutgers University, 599 Taylor Road, Piscataway, NJ 08854, USA. manjari.b@rutgers.edu.
Laura FabrisDepartment of Materials Science and Engineering, Rutgers University, 607 Taylor Road, Piscataway, NJ 08854, USA. lfabris@soe.rutgers.edu.

Funding

Ministero dell'Istruzione, dell'Università e della Ricerca FIRB project ITALNANONET (RBPR05JH2P_001)
6 · The paper itself

Abstract

Surface-enhanced Raman scattering (SERS) has become a powerful tool in chemical, material and life sciences, owing to its intrinsic features (i.e., fingerprint recognition capabilities and high sensitivity) and to the technological advancements that have lowered the cost of the instruments and improved their sensitivity and user-friendliness. We provide an overview of the most significant aspects of SERS. First, the phenomena at the basis of the SERS amplification are described. Then, the measurement of the enhancement and the key factors that determine it (the materials, the hot spots, and the analyte-surface distance) are discussed. A section is dedicated to the analysis of the relevant factors for the choice of the excitation wavelength in a SERS experiment. Several types of substrates and fabrication methods are illustrated, along with some examples of the coupling of SERS with separation and capturing techniques. Finally, a representative selection of applications in the biomedical field, with direct and indirect protocols, is provided. We intentionally avoided using a highly technical language and, whenever possible, intuitive explanations of the involved phenomena are provided, in order to make this review suitable to scientists with different degrees of specialization in this field.

Indexed as

Biosensing TechniquesAnimalsBacteriaDNAHumansProteinsSpectrum Analysis, RamanSurface PropertiesVirusesDNAProteinsbiomedical applicationschemical enhancementelectromagnetic enhancementenhancement factorexcitation wavelengthRamanSERSsubstratessurface enhancedunderpotential deposition

Identifiers

PMID30999661
PMCPMC6627380

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.