ArticleMolecules (Basel, Switzerland)2019
Lipophilicity as a Central Component of Drug-Like Properties of Chalchones and Flavonoid Derivatives.
Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
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- Study of the Lipophilicity of Tetracyclic Anticancer Azaphenothiazines.Biomolecules · 2025Article
- Aniline Derivatives Containing 1-Substituted 1,2,3-Triazole System as Potential Drug Candidates: Pharmacokinetic Profile Prediction, Lipophilicity Analysis Using Experimental and In Silico Studies.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Revisiting the Application of Machine Learning Approaches in Predicting Aqueous Solubility.ACS omega · 2024Article
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- Comparison of HPLC, HPTLC, and In Silico Lipophilicity Parameters Determined for 5-Heterocyclic 2-(2,4-Dihydroxyphenyl)-1,3,4-thiadiazoles.Molecules (Basel, Switzerland) · 2024Article
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- The Chemical Space of Marine Antibacterials: Diphenyl Ethers, Benzophenones, Xanthones, and Anthraquinones.Molecules (Basel, Switzerland) · 2023Article
- Study of Lipophilicity and ADME Properties of 1,9-Diazaphenothiazines with Anticancer Action.International journal of molecular sciences · 2023Article
- Assessment of Lipophilicity Parameters of Antimicrobial and Immunosuppressive Compounds.Molecules (Basel, Switzerland) · 2023Article
- Synthesis and Development ofAntibiotics (Basel, Switzerland) · 2023Article
- Comparative Study of the Lipophilicity of Selected Anti-Androgenic and Blood Uric Acid Lowering Compounds.Molecules (Basel, Switzerland) · 2022Article
- Two Important Anticancer Mechanisms of Natural and Synthetic Chalcones.International journal of molecular sciences · 2022Review
- Lipophilicity and Pharmacokinetic Properties of New Anticancer Dipyridothiazine with 1,2,3-Triazole Substituents.Molecules (Basel, Switzerland) · 2022Article
- A Comparative Study of the Lipophilicity of Metformin and Phenformin.Molecules (Basel, Switzerland) · 2021Article
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3 authors.
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Abstract
Lipophilcity is an important physico-chemical parameter that influences membrane transport and binding ability to action. Migration distance following complete elution of compounds was used to calculate different lipophilicity-related parameters. The aim of this study is to show that lipophilicity is a central component of thiazole chalcones and flavonoid derivatives regarding their drug-like properties. Experimental and computational methods were used. This study considers 44 previously synthesized compounds (thiazole chalcones, flavanones, flavones, 3-hydroxyflavones, and their acetylated derivatives). The concerned compounds have shown antitumoral hallmarks and antibacterial activity in vitro. The experimental method used to determine compounds' lipophilicity was the reverse-phase thin layer chromatography (RP-TLC). Lipophilicity related parameters-isocratic retention factor (R
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