Evidence map›Paper›PMID 30999586›Full record

ArticleMolecules (Basel, Switzerland)2019

QuinoxalineTacrine QT78, a Cholinesterase Inhibitor as a Potential Ligand for Alzheimer's Disease Therapy.

Eva Ramos, Alejandra Palomino-Antolín, Manuela Bartolini, Isabel Iriepa, Ignacio Moraleda, Daniel Diez-Iriepa, Abdelouahid Samadi, Carol V Cortina, Mourad Chioua, Javier Egea and 2 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
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  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Eva RamosDepartment of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Complutense University of Madrid, 28040 Madrid, Spain. eva.ramos@ucm.es.ORCID 0000-0001-5791-0687
Alejandra Palomino-AntolínMolecular Neuroinflammation and Neuronal Plasticity Laboratory, Research Unit, Hospital Universitario Santa Cristina, 28009 Madrid, Spain. apantolin@gmail.com.
Manuela BartoliniDepartment of Pharmacy and Biotechnology, Alma Mater Studiorum University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy. manuela.bartolini3@unibo.it.ORCID 0000-0002-2890-3856
Isabel IriepaDepartamento de Química Orgánica and Química Inorgánica. Ctra. Madrid-Barcelona, Km. 33,6. Universidad de Alcalá, 28871 Madrid, Spain. isabel.iriepa@uah.es.
Ignacio MoraledaDepartamento de Química Orgánica and Química Inorgánica. Ctra. Madrid-Barcelona, Km. 33,6. Universidad de Alcalá, 28871 Madrid, Spain. ignacio.moraleda@uah.es.
Daniel Diez-IriepaDepartamento de Química Orgánica and Química Inorgánica. Ctra. Madrid-Barcelona, Km. 33,6. Universidad de Alcalá, 28871 Madrid, Spain. daniel.diezi@edu.uah.es.
Abdelouahid SamadiLaboratory of Medicinal Chemistry (IQOG, CSIC), C/Juan de la Cierva 3, 28006 Madrid, Spain. samadi@uaeu.ac.ae.
Carol V CortinaLaboratory of Medicinal Chemistry (IQOG, CSIC), C/Juan de la Cierva 3, 28006 Madrid, Spain. cvcortina@gmail.com.
Mourad ChiouaLaboratory of Medicinal Chemistry (IQOG, CSIC), C/Juan de la Cierva 3, 28006 Madrid, Spain. mchioua@gmail.com.
Javier EgeaMolecular Neuroinflammation and Neuronal Plasticity Laboratory, Research Unit, Hospital Universitario Santa Cristina, 28009 Madrid, Spain. javier.egea@inv.uam.es.ORCID 0000-0003-4704-3019
Alejandro RomeroDepartment of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Complutense University of Madrid, 28040 Madrid, Spain. manarome@ucm.es.ORCID 0000-0001-5483-4973
José Marco-ContellesLaboratory of Medicinal Chemistry (IQOG, CSIC), C/Juan de la Cierva 3, 28006 Madrid, Spain. iqoc21@iqog.csic.es.
Instituto de Química Orgánica General · ESUniversidad de Alcalá · ESHospital Universitario Santa Cristina · ESUniversidad Complutense de Madrid · ESUnited Arab Emirates University · AEUniversity of Bologna · IT

Funding

Fondo de Investigaciones Sanitarias Programa Miguel Servet CP14/00008; PI16/00735Instituto de Salud Carlos III [RED RENEVAS (RD06/0026/1002)]Ministerio de Ciencia e Innovación SAF2006-08764-C02-01
6 · The paper itself

Abstract

We report the synthesis and relevant pharmacological properties of the quinoxalinetacrine (QT) hybrid

Indexed as

Cholinesterase InhibitorsTacrineAlzheimer DiseaseHep G2 CellsHumansCholinesterase InhibitorsTacrineAlzheimer’s diseasecholinesterase inhibitorhepatotoxicitymolecular modelingneuroprotectionquinoxalinesquinoxalinetacrinestacrine

Identifiers

PMID30999586
PMCPMC6514705
OpenAlexW2936023333

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.