ArticleMolecules (Basel, Switzerland)2019
A Noninvasive Accurate Measurement of Blood Glucose Levels with Raman Spectroscopy of Blood in Microvessels.
Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 96 citations in OpenAlex.
- Developing an Integrated Toolbox for Raman Spectral Analysis with Both Artificial Neural Networks and Machine Learning Algorithms.Molecules (Basel, Switzerland) · 2026Article
- A Linear and High-Sensitivity Microwave Biosensor on a FR-4 Substrate for Aqueous Glucose Monitoring Using a Concentric Square-Shaped Split-Ring Resonator.Sensors (Basel, Switzerland) · 2025Article
- Blood component analysis using mid-infrared photoacoustic spectroscopy based on ultrasound detection: glucose analysis trial.Journal of biomedical optics · 2025Article
- Non-contact measurement of glucose in urine by smartphone-based laser refractometry for diabetes monitoring.Scientific reports · 2025Article
- Noninvasive Analysis of Biological Components Using Simplified Mid-Infrared Photothermal Deflection Spectroscopy.Sensors (Basel, Switzerland) · 2025Article
- Analysis of glucose concentrations in blood solutions using FTIR and Raman spectroscopy methods.Biomedical optics express · 2025Article
- Article
- Clinical evaluation of a polarization-based optical noninvasive glucose sensing system.Scientific reports · 2025Article
- Diagnosis of pregnancy disorder in the first-trimester patient plasma with Raman spectroscopy and protein analysis.Bioengineering & translational medicine · 2024Article
- Design and Validation of a Monte Carlo Method for the Implementation of Noninvasive Wearable Devices for HbA1c Estimation Considering the Skin Effect.Micromachines · 2024Article
- Article
- Noninvasive Glucose Measurements Through Transcutaneous Raman Spectroscopy: A Review.Journal of diabetes science and technology · 2024Review
- Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus.Diabetes care · 2023Review
- Noninvasive Glucose Sensing In Vivo.Sensors (Basel, Switzerland) · 2023Review
- Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus.Clinical chemistry · 2023Article
- Mid-infrared photoacoustic spectroscopy based on ultrasound detection for blood component analysis.Biomedical optics express · 2023Article
- Glucose diagnosis system combining machine learning and NIR photoacoustic multispectral using a low power CW laser.Biomedical optics express · 2023Article
- Commercial and Scientific Solutions for Blood Glucose Monitoring-A Review.Sensors (Basel, Switzerland) · 2022Review
- Is Raman the best strategy towards the development of non-invasive continuous glucose monitoring devices for diabetes management?Frontiers in chemistry · 2022Review
- Proof of Concept for a New Raman-Based Prototype for Noninvasive Glucose Monitoring.Journal of diabetes science and technology · 2021Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Raman spectra of human skin obtained by laser excitation have been used to non-invasively detect blood glucose. In previous reports, however, Raman spectra thus obtained were mainly derived from the epidermis and interstitial fluid as a result of the shallow penetration depth of lasers in skin. The physiological process by which glucose in microvessels penetrates into the interstitial fluid introduces a time delay, which inevitably introduces errors in transcutaneous measurements of blood glucose. We focused the laser directly on the microvessels in the superficial layer of the human nailfold, and acquired Raman spectra with multiple characteristic peaks of blood, which indicated that the spectra obtained predominantly originated from blood. Incorporating a multivariate approach combining principal component analysis (PCA) and back propagation artificial neural network (BP-ANN), we performed noninvasive blood glucose measurements on 12 randomly selected volunteers, respectively. The mean prediction performance of the 12 volunteers was obtained as an RMSEP of 0.45 mmol/L and R
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.