Evidence map›Paper›PMID 30999563›Full record

ArticleInternational journal of molecular sciences2019

Physiological Responses of Jurkat Lymphocytes to Simulated Microgravity Conditions.

Caterina Morabito, Paola Lanuti, Giusy A Caprara, Marco Marchisio, Mariano Bizzarri, Simone Guarnieri, Maria A Mariggiò

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Omics Studies of Tumor Cells under Microgravity Conditions.International journal of molecular sciences · 2024
    Review
  5. Article
  6. Microgravity and immune cells.Journal of the Royal Society, Interface · 2023
    Review
  7. Article
  8. Review
  9. Engineered Microvessel for Cell Culture in Simulated Microgravity.International journal of molecular sciences · 2021
    Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Caterina MorabitoDepartment of Neuroscience, Imaging and Clinical Sciences, University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy. cmorabit@unich.it.
Paola LanutiCentro Scienze dell' Invecchiamento e Medicina Traslazionale (CeSI-MeT), University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy. paola.lanuti@unich.it.
Giusy A CapraraDepartment of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. GIUSY.CAPRARA@UCDENVER.EDU.
Marco MarchisioCentro Scienze dell' Invecchiamento e Medicina Traslazionale (CeSI-MeT), University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy. marco.marchisio@unich.it.
Mariano BizzarriDepartment of Experimental Medicine, Sapienza University of Rome, 06100 Rome, Italy. mariano.bizzarri@uniroma1.it.ORCID 0000-0003-0408-4136
Simone GuarnieriDepartment of Neuroscience, Imaging and Clinical Sciences, University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy. guarnie@unich.it.
Maria A MariggiòDepartment of Neuroscience, Imaging and Clinical Sciences, University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy. mariggio@unich.it.ORCID 0000-0001-5306-7143
University of Chieti-Pescara · ITSapienza University of Rome · ITUniversity of Colorado Anschutz Medical Campus · US

Funding

Agenzia Spaziale Italiana 2014-018-R.O
6 · The paper itself

Abstract

The presence of microgravity conditions deeply affects the human body functions at the systemic, organ and cellular levels. This study aimed to investigate the effects induced by simulated-microgravity on non-stimulated Jurkat lymphocytes, an immune cell phenotype considered as a biosensor of the body responses, in order to depict at the cellular level the effects of such a peculiar condition. Jurkat cells were grown at 1 g or on random positioning machine simulating microgravity. On these cells we performed: morphological, cell cycle and proliferation analyses using cytofluorimetric and staining protocols-intracellular Ca

Indexed as

Weightlessness SimulationCalciumCell ShapeGlucoseHumansJurkat CellsLymphocytesMembrane Potential, MitochondrialOxidative StressOxygenCalciumGlucoseOxygencell shapecytoskeletal remodellinglymphocytesoxidative stresssimulated-microgravity

Identifiers

PMID30999563
PMCPMC6515345
OpenAlexW2940223973

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.