Trial reportNutrients2019
Combined Effect of Arginine, Valine, and Serine on Exercise-Induced Fatigue in Healthy Volunteers: A Randomized, Double-Blinded, Placebo-Controlled Crossover Study.
Trial report in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Efficacy and Safety of Enzyme-Derived Deer Velvet Extract Supplementation on Adults with Chronic Fatigue: a Randomized, Placebo-Controlled, Double-Blind Trial.Journal of microbiology and biotechnology · 2026Trial
- Trial
- Ice slurry ingestion improves physical performance during high-intensity intermittent exercise in a hot environment.PloS one · 2022Trial
- Acute supplementation with an amino acid mixture suppressed the exercise-induced cortisol response in recreationally active healthy volunteers: a randomized, double-blinded, placebo-controlled crossover study.Journal of the International Society of Sports Nutrition · 2020Trial
- Review
- A study on the nutritional composition and shelf-life of Hanwoo cattle bone items during retail display.Food science of animal resources · 2026Article
- Changes of plasma amino acid levels and metabolic pathways in isotretinoin therapy: ınsights into managing acne vulgaris side effects.Archives of dermatological research · 2025Article
- Possible effect of exercise with anti-fatigue nutrition on ROS-induced depression and suicide risk: a review.Physical activity and nutrition · 2024Article
- The Effects of Arginine-Based Supplements on Fatigue Levels following COVID-19 Infection: A Prospective Study in Romania.Healthcare (Basel, Switzerland) · 2023Article
- Milk Fat Globule Membrane Relieves Fatigue via Regulation of Oxidative Stress and Gut Microbiota in BALB/c Mice.Antioxidants (Basel, Switzerland) · 2023Article
- Comparison of the effects of pea protein and whey protein on the metabolic profile of soccer athletes: a randomized, double-blind, crossover trial.Frontiers in nutrition · 2023Article
- Anti-Fatigue Peptides from the Enzymatic Hydrolysates ofMolecules (Basel, Switzerland) · 2021Article
- The effect of zinc supplementation on fatigue among elderly community dwellers: A parallel clinical trial.Health science reports · 2021Article
- Impact of Moriamin Forte on Testicular and Epididymal Damage in Rats with Oligoasthenospermia.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Amino Acid Nutrition and Metabolism in Health and Disease.Nutrients · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although several kinds of amino acids (AAs) are known to affect physiological actions during exercise, little is known about the combined effects of a mixture of several AAs on fatigue during exercise. The aim of the present study was to investigate the effect of an AA mixture supplement containing arginine, valine, and serine on exercise-induced fatigue in healthy volunteers. These AAs were selected because they were expected to reduce fatigue during exercise by acting the positive effects synergistically. A randomized, double-blinded, placebo-controlled crossover trial was conducted. Thirty-nine males ingested an AA mixture containing 3600 mg of arginine, 2200 mg of valine, and 200 mg of serine or a placebo each day for 14 days. On the 14th day, the participants completed an exercise trial on a cycle ergometer at 50% of VO
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.