Evidence map›Paper›PMID 30999302›Full record

ArticlePublic health genomics2018

Psychological Impact of Learning CDKN2A Variant Status as a Genetic Research Result.

Xuan Zhu, Emma R Leof, Kari G Rabe, Jennifer B McCormick, Gloria M Petersen, Carmen Radecki Breitkopf

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Public health genomics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Xuan ZhuDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
Emma R LeofInfectious Disease Epidemiology, Prevention, and Control Division, Minnesota Department of Health, St. Paul, Minnesota, USA.
Kari G RabeDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
Jennifer B McCormickDepartment of Humanities, College of Medicine, Pennsylvania State University, Hershey, Pennsylvania, USA.
Gloria M PetersenDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
Carmen Radecki BreitkopfDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA, RadeckiBreitkopf.Carmen@mayo.edu.
Mayo Clinic in Florida · USMayo Clinic · USMinnesota Department of Health · USPennsylvania State University · US

Funding

Pancreatic Cancer Genetic Epidemiology Consortium (PACGENE)R01CA097075 · NCI · MAYO CLINIC ROCHESTER · PI PETERSEN, GLORIA M. · 2002 to 2012
$15.8M
Determinants of pancreatic cancer and malignant melanoma phenotypes in CDKN2A hereditary kindredsR01CA208517 · NCI · MAYO CLINIC ROCHESTER · PI FERNANDEZ-ZAPICO, MARTIN ERNESTO, LI, HU · 2016 to 2020
$2.9M
NCI NIH HHS R01 CA097075NCI NIH HHS R01 CA208517
6 · The paper itself

Abstract

objectivesLittle is known about genetic research participants' responses to receiving individual research results (IRR) from cancer genetic research. We examined the immediate and delayed psychological impact of returning a CDKN2A variant result that is associated with increased risk of pancreatic cancer and melanoma.

methodsOne hundred and thirty-three pancreas research registry enrollees whose samples were tested in a research laboratory for the CDKN2A variant were invited by mail to learn the result by telephone and participate in a study about the disclosure process. Self-rated health, quality of life, and emotional responses were surveyed before and 6 months after disclosure. Genetic testing-specific distress, uncertainty, and positive experiences were assessed 6 months after disclosure.

resultsEighty individuals agreed to participate; 63 completed the study. Both carriers and noncarriers showed no change over time in self-rated health, quality of life, or anxiety levels. Carriers reported more sadness than noncarriers before and 6 months after disclosure. Both carriers and noncarriers showed more hopefulness 6 months after than before disclosure. Carriers experienced greater test-specific distress and uncertainty than noncarriers, but levels were low. -Conclusions: Return of IRR in conjunction with cancer prevention counseling led to low levels of test-specific distress and uncertainty among carriers. No other adverse psychological outcomes were observed.

Indexed as

Genetic TestingTruth DisclosureAdultAgedAged, 80 and overFemaleGenes, p16Genetic Predisposition to DiseaseHumansMaleMiddle AgedMutationPancreatic NeoplasmsSurveys and QuestionnairesCDKN2A variantGenetic research resultsMelanomaPancreatic cancerPsychological outcome

Identifiers

PMID30999302
PMCPMC6760672
OpenAlexW2937202715

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.