ArticlePsychoneuroendocrinology2019
Comparability of biological aging measures in the National Health and Nutrition Examination Study, 1999-2002.
Article in Psychoneuroendocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
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Who cites it
77 citing papers in PubMed, 139 citations in OpenAlex.
- Effect of long-term caloric restriction on telomere length in healthy adults: CALERIE™ 2 trial analysis.Aging cell · 2024Trial
- Effect of Diet, Exercise, or Both on Biological Age and Healthy Aging in Older Adults with Obesity: Secondary Analysis of a Randomized Controlled Trial.The journal of nutrition, health & aging · 2022Trial
- Physiological Age and Homeostatic Dysregulation Following Child Maltreatment in Youth.Molecular psychiatry · 2026Article
- Cross-Sectional and Longitudinal Association Between Biological Aging Acceleration and the Risk of Osteoarthritis: A Cohort Study From UK Biobank.International journal of rheumatic diseases · 2026Article
- Frequent Sweetened Beverage Consumption Is Associated With Accelerated Biological Aging: Evidence From a Population-Based Study and Gut Microbiota Analysis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Joint effects of social determinants of health on NAFLD mortality: the mediating role of phenotypic age acceleration.GeroScience · 2026Article
- Association between biological aging and clinical mortality among patients with rheumatoid arthritis.Clinical rheumatology · 2026Article
- Joint association of serum 25-hydroxyvitamin D concentration and body mass index on the acceleration of clinical biomarker-based biological aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Biological ageing, diet quality, and stroke: evidence from two population-based studies and an exploratory hospital-based Chinese cross-sectional dataset.Frontiers in nutrition · 2026Article
- Molecular markers, mechanisms and metrics of biological aging: a scoping review.Frontiers in aging · 2026Review
- Association Between Neutrophil Percentage-Albumin Ratio and Biological Aging in Rheumatoid Arthritis in the United States: A Cross-Sectional Study of NHANES.Mediators of inflammation · 2026Article
- Social determinants of health, accelerated biological aging, and long-term health outcomes.Nature communications · 2025Article
- Racial and Social Inequities in Weathering: the ELSA-Brasil Cohort.Journal of racial and ethnic health disparities · 2025Article
- Association of body roundness index with risk of all-cause, cardiovascular disease-cause, and cancer-cause mortality: the role of biological age acceleration.Nutrition journal · 2025Article
- Association between blood-derived biological aging and bone mineral density among US adults.BMC musculoskeletal disorders · 2025Article
- No winners or losers: clinical chemistry-based biological aging metrics perform similarly across cohorts and health outcomes.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Association between aging phenotypes and chronic kidney disease: evidence from the NHANES and Mendelian randomization.International urology and nephrology · 2025Article
- Biological Age as a Predictor of Arterial Stiffness in Young and Early Midlife Black and White Women.American journal of hypertension · 2025Article
- Genetic risk predicts adolescent mood pathology via sexual differentiation of brain function and physiological aging.Nature communications · 2025Article
- Associations between shift work and biological age acceleration: A population-based study.GeroScience · 2025Article
17 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundBiological processes of aging are thought to be modifiable causes of many different chronic diseases. Measures of biological aging could provide sensitive endpoints for studies of risk factors hypothesized to shorten healthy lifespan and/or interventions that extend it. But uncertainty remains about how to measure biological aging and if proposed measures assess the same thing.
methodWe tested four proposed measures of biological aging that could be quantified with available data from the National Health and Nutrition Examination Survey (NHANES), Klemera-Doubal method (KDM) Biological Age, homeostatic dysregulation, Levine Method (LM) Biological Age, and leukocyte telomere length.
resultsWe analyzed data collected during 1999-2002, when all four biological aging meausres could be taken. Participants' KDM biological ages, homeostatic dysregulation levels, LM biological ages, and telomere length were all correlated with their chronological ages. KDM Biological Age, homeostatic dysregulation, and LM Biological Age were all correlated with one another, but these measures were uncorrelated with telomere length. Participants' with more advanced biological aging performed worse on tests of physical, cognitive, and perceptual functioning and reported more limitations to their daily activities and more pain, and rated themselves as being in worse health. In parallel, participants with risk factors for shorter healthy lifespan exhibited more advanced biological aging. In both sets of analyses, effect-sizes tended to be larger for KDM Biological Age, homeostatic dysregulation, and LM Biological Age as compared to telomere length. DISCUSSION: The cellular-level aging biomarker telomere length may measure different aspects of the aging process as compared to the patient-level physiological composite measures KDM Biological Age, homeostatic dysregulation, and LM Biological Age. Studies aiming to test if risk factors accelerate aging or if interventions may slow aging should not treat proposed measures of aging as interchangeable.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.