Evidence map›Paper›PMID 30998945›Full record

ArticleNeuropharmacology2019

Roles of K

Huiming Li, Binqi Hu, Hao-Peng Zhang, Cody A Boyle, Saobo Lei

Open access · greenAbstract read
In one paragraph

Article in Neuropharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.0field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. KPhysiological reports · 2022
    Article
  8. Roles of PLCβ, PIPJournal of cellular physiology · 2022
    Article
  9. Article
  10. Activation of VNeuropharmacology · 2021
    Article
  11. Article
  12. Neuromodulation of Astrocytic KInternational journal of molecular sciences · 2021
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Huiming LiDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, 58203, USA.
Binqi HuDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, 58203, USA.
Hao-Peng ZhangDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, 58203, USA.
Cody A BoyleDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, 58203, USA.
Saobo LeiDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, 58203, USA. Electronic address: saobo.lei@und.edu.
University of North Dakota · US

Funding

Cellular and molecular mechanisms of vasopressin in anxietyR01MH118258 · NIMH · UNIVERSITY OF NORTH DAKOTA · PI LEI, SAOBO · 2019 to 2023
$1.5M
Cellular and molecular mechanisms of vasopressin in anxietyR56MH118258 · NIMH · UNIVERSITY OF NORTH DAKOTA · PI LEI, SAOBO · 2019 to 2019
$232k
NIMH NIH HHS R01 MH118258NIMH NIH HHS R56 MH118258
6 · The paper itself

Abstract

Nociceptin (NOP) is an endogenous opioid-like peptide that selectively activates the opioid receptor-like (ORL-1) receptors. The entorhinal cortex (EC) is closely related to temporal lobe epilepsy and expresses high densities of ORL-1 receptors. However, the functions of NOP in the EC, especially in modulating the epileptiform activity in the EC, have not been determined. We demonstrated that activation of ORL-1 receptors remarkably inhibited the epileptiform activity in entorhinal slices induced by application of picrotoxin or by deprivation of extracellular Mg

Indexed as

Action PotentialsAnimalsEntorhinal CortexNociceptinNociceptin ReceptorOpioid PeptidesPotassium Channel BlockersPotassium ChannelsPyramidal CellsRatsRats, Sprague-DawleyReceptors, OpioidSynaptic TransmissionNociceptinNociceptin ReceptorOpioid PeptidesOprl1 protein, ratPotassium Channel BlockersPotassium ChannelsReceptors, OpioidAction potentialCortexEpilepsyGlutamateHippocampusHyperpolarizationK(+) channelsNeuropeptideSynaptic transmission

Identifiers

PMID30998945
PMCPMC6500758
OpenAlexW2938687231

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.