ArticlePLoS pathogens2019
βC1 protein encoded in geminivirus satellite concertedly targets MKK2 and MPK4 to counter host defense.
Article in PLoS pathogens, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 72 citations in OpenAlex.
- The zig-zag model of molecular defense and counterdefense in plant-herbivore interactions.Planta · 2026Review
- Fine-tuning of the CRWN2-NTL9 module to repress PR1 expression by a viral effector during geminivirus infection.Fundamental research · 2026Article
- The multidimensional significance of virus-host protein interactions and their implications in the antiviral defense of plants.Stress biology · 2026Review
- RD21 enhances resistance to the strawberry vein banding virus by promoting autophagy-mediated degradation of the viral silencing suppressor P6 protein.Plant biotechnology journal · 2025Article
- Whitefly transmitted begomovirus infection in plant and host response: a review.Physiology and molecular biology of plants : an international journal of functional plant biology · 2025Review
- From perception to action: MAPKs in plant-virus interactions.Physiology and molecular biology of plants : an international journal of functional plant biology · 2025Review
- Geminivirus βV1 protein activates bZIP17/28-mediated UPR signaling to facilitate viral pathogenicity but its activity is attenuated by autophagic degradation in plants.Plant communications · 2025Article
- Advances in understanding the interaction betweenPlant signaling & behavior · 2024Review
- Transcriptomic profiling reveals distinct responses to beet curly top virus (BCTV) infection in resistant and susceptible sugar beet genotypes.BMC genomics · 2024Article
- A viral protein activates the MAPK pathway to promote viral infection by downregulating callose deposition in plants.Nature communications · 2024Article
- Use of CRISPR Technology in Gene Editing for Tolerance to Biotic Factors in Plants: A Systematic Review.Current issues in molecular biology · 2024Review
- Activation of MAPK-mediated immunity by phosphatidic acid in response to positive-strand RNA viruses.Plant communications · 2024Article
- Leafhopper salivary vitellogenin mediates virus transmission to plant phloem.Nature communications · 2024Article
- A papain-like cysteine protease-released small signal peptide confers wheat resistance to wheat yellow mosaic virus.Nature communications · 2023Article
- Geminiviral betasatellites: critical viral ammunition to conquer plant immunity.Archives of virology · 2023Review
- Pseudomonas syringae Type III Secretion Protein HrpP Manipulates Plant Immunity To Promote Infection.Microbiology spectrum · 2023Article
- Review
- Identification and Functional Analyses of Host Proteins Interacting with the P3a Protein of Brassica Yellows Virus.Biology · 2023Article
- A sword or a buffet: plant endomembrane system in viral infections.Frontiers in plant science · 2023Review
- Evasion of plant immunity by microbial pathogens.Nature reviews. Microbiology · 2022Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Plant viruses have evolved multiple strategies to overcome host defense to establish an infection. Here, we identified two components of a host mitogen-activated protein kinase (MAPK) cascade, MKK2 and MPK4, as bona fide targets of the βC1 protein encoded by the betasatellite of tomato yellow leaf curl China virus (TYLCCNV). βC1 interacts with the kinase domain of MKK2 and inhibits its activity. In vivo, βC1 suppresses flagellin-induced MAPK activation and downstream responses by targeting MKK2. Furthermore, βC1 also interacts with MPK4 and inhibits its kinase activity. TYLCCNV infection induces the activation of the MAPK cascade, mutation in MKK2 or MPK4 renders the plant more susceptible to TYLCCNV, and can complement the lack of βC1. This work shows for the first time that a plant virus both activates and suppresses a MAPK cascade, and the discovery of the ability of βC1 to selectively interfere with the host MAPK activation illustrates a novel virulence function and counter-host defense mechanism of geminiviruses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.