ArticlePloS one2019
A mouse model of cochlear implantation with chronic electric stimulation.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- Development of zwitterionic hydrogel thin film coatings of cochlear implant electrode arrays that reduce intracochlear inflammation and electrode impedance.Hearing research · 2026Article
- Spatiotemporal Dynamics of Cochlear Implant Electrode Impedance in Standard and Dexamethasone-Eluting Electrode Arrays.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2026Article
- Dexamethasone-eluting cochlear implants reduce inflammation and foreign body response in human and murine cochleae.Scientific reports · 2025Article
- Impact of Cochlear Trauma Degree and Localization on Intracochlear Electrocochleographic Recordings.Audiology research · 2025Article
- Micro-CT Analysis of Rodent Temporal Bones: Identifying Optimal Species for Otological Research.Laryngoscope investigative otolaryngology · 2025Article
- Electrode impedance dynamics in sequential cochlear implant users: insights into cochlear immunity.Frontiers in immunology · 2025Article
- Animal models of cochlear implant: Classification and update.Journal of otology · 2024Review
- A Virtual Inner Ear Model Selects Ramped Pulse Shapes for Vestibular Afferent Stimulation.Bioengineering (Basel, Switzerland) · 2023Article
- Sheep as a large animal model for hearing research: comparison to common laboratory animals and humans.Laboratory animal research · 2023Review
- Contribution of macrophages to neural survival and intracochlear tissue remodeling responses following cochlear implantation.Journal of neuroinflammation · 2023Article
- Electrical stimulation of cochlear implant promotes activation of macrophages and fibroblasts under inflammation.Laryngoscope investigative otolaryngology · 2023Article
- Models of Cochlea Used in Cochlear Implant Research: A Review.Annals of biomedical engineering · 2023Review
- Article
- Comparative Analysis of Robotics-Assisted and Manual Insertions of Cochlear Implant Electrode Arrays.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2022Article
- Cochlear implant material effects on inflammatory cell function and foreign body response.Hearing research · 2022Article
- Cochlear implants: Causes, effects and mitigation strategies for the foreign body response and inflammation.Hearing research · 2022Review
- Development and Characterization of an Electrocochleography-Guided Robotics-Assisted Cochlear Implant Array Insertion System.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2022Article
- Development of a chronically-implanted mouse model for studies of cochlear health and implant function.Hearing research · 2021Article
- An evaluation framework for research platforms to advance cochlear implant/hearing aid technology: A case study with CCi-MOBILE.The Journal of the Acoustical Society of America · 2021Article
- Auditory cortical plasticity in cochlear implant users.Current opinion in neurobiology · 2020Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesCochlear implants provide an effective treatment option for those with severe hearing loss, including those with preserved low frequency hearing. However, certain issues can reduce implant efficacy including intracochlear tissue response and delayed loss of residual acoustic hearing. We describe a mouse model of cochlear implantation with chronic electric stimulation that can be used to study cochlear implant biology and related pathologies.
methodsTwelve normal hearing adult CBA/J mice underwent unilateral cochlear implantation and were evenly divided into one group receiving electric stimulation and one not. Serial impedance and neural response telemetry (NRT) measurements were made to assess implant functionality. Functionality was defined as having at least one electrode with an impedance ≤ 35 kOhms. Mouse cochleae were harvested for histology and 3D x-ray microscopy 21 days post-operatively, or, in case the implant was still functional, at a later time point when the implant failed. A separate experiment measured the hearing preservation rate in 7 adult CBA/J mice undergoing unilateral cochlear implantation with serial auditory brainstem response (ABR) and distortion product otoacoustic emissions (DPOAE).
resultsImplants maintained functionality for a mean of 35 days in the non-stimulated group and 19.8 days in the stimulated group. Reliable NRT and behavioral responses to electric stimulation were recorded. A robust intracochlear peri-implant tissue response with neo-ossification was seen in all cochleae. Six of seven mice maintained intact low frequency hearing up to 6 weeks following cochlear implantation.
conclusionsWe demonstrate the feasibility of cochlear implantation and behaviorally significant electric stimulation in the mouse, with the potential for hearing preservation. This model may be combined with established mouse models of hearing loss and the large genetic and molecular research toolkit unique to the mouse for mechanistic and therapeutic investigations of cochlear implant biology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.