ArticlePLoS computational biology2019
Bet-hedging strategies in expanding populations.
Article in PLoS computational biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Bet-hedging via Kelly betting in a limited environment leads to logistic growth in the Game of Fitness.Scientific reports · 2026Article
- A nutrient bottleneck controls antibiotic efficacy in structured bacterial populations.Nature communications · 2026Article
- The Constrained Disorder Principle: A Paradigm Shift for Accurate Interactome Mapping and Information Analysis in Complex Biological Systems.Bioengineering (Basel, Switzerland) · 2025Review
- Margins of adaptation at the desert frontier: genetic responses of Ammopiptanthus mongolicus in arid northwestern China.Botanical studies · 2025Review
- Structure and dynamics of enterovirus genotype networks.Science advances · 2024Article
- Long-term aquarium records delineate the synchronized spawning strategy ofRoyal Society open science · 2024Article
- Efficient design of synthetic gene circuits under cell-to-cell variability.BMC bioinformatics · 2023Article
- Gauge-and-compass migration: inherited magnetic headings and signposts can adapt to changing geomagnetic landscapes.Movement ecology · 2023Article
- Effective bet-hedging through growth rate dependent stability.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- "Bet hedging" against climate change in developing and adult animals: roles for stochastic gene expression, phenotypic plasticity, epigenetic inheritance and adaptation.Frontiers in physiology · 2023Review
- Collective behavior and nongenetic inheritance allow bacterial populations to adapt to changing environments.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Article
- Diversity of bet-hedging strategies in microbial communities-Recent cases and insights.WIREs mechanisms of disease · 2022Review
- Population Density Affects the Outcome of Competition in Co-cultures of Gardnerella Species Isolated from the Human Vaginal Microbiome.Microbial ecology · 2022Article
- Phages for Africa: The Potential Benefit and Challenges of Phage Therapy for the Livestock Sector in Sub-Saharan Africa.Antibiotics (Basel, Switzerland) · 2021Review
- Phenotypic-dependent variability and the emergence of tolerance in bacterial populations.PLoS computational biology · 2021Article
- A prion-like protein regulator of seed germination undergoes hydration-dependent phase separation.Cell · 2021Article
- Temporal fluctuations in chemotaxis gain implement a simulated-tempering strategy for efficient navigation in complex environments.iScience · 2021Article
- Spatial Bet Hedging in Sand Fly Oviposition: Factors Affecting Skip Oviposition inVector borne and zoonotic diseases (Larchmont, N.Y.) · 2021Article
- Persistence as an Optimal Hedging Strategy.Biophysical journal · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In ecology, species can mitigate their extinction risks in uncertain environments by diversifying individual phenotypes. This observation is quantified by the theory of bet-hedging, which provides a reason for the degree of phenotypic diversity observed even in clonal populations. Bet-hedging in well-mixed populations is rather well understood. However, many species underwent range expansions during their evolutionary history, and the importance of phenotypic diversity in such scenarios still needs to be understood. In this paper, we develop a theory of bet-hedging for populations colonizing new, unknown environments that fluctuate either in space or time. In this case, we find that bet-hedging is a more favorable strategy than in well-mixed populations. For slow rates of variation, temporal and spatial fluctuations lead to different outcomes. In spatially fluctuating environments, bet-hedging is favored compared to temporally fluctuating environments. In the limit of frequent environmental variation, no opportunity for bet-hedging exists, regardless of the nature of the environmental fluctuations. For the same model, bet-hedging is never an advantageous strategy in the well-mixed case, supporting the view that range expansions strongly promote diversification. These conclusions are robust against stochasticity induced by finite population sizes. Our findings shed light on the importance of phenotypic heterogeneity in range expansions, paving the way to novel approaches to understand how biodiversity emerges and is maintained.
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