Evidence map›Paper›PMID 30998413›Full record

ArticleAmerican journal of public health2019

Does Despair Really Kill? A Roadmap for an Evidence-Based Answer.

Lilly Shanahan, Sherika N Hill, Lauren M Gaydosh, Annekatrin Steinhoff, E Jane Costello, Kenneth A Dodge, Kathleen Mullan Harris, William E Copeland

Open access · greenAbstract read
In one paragraph

Article in American journal of public health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 1 pooled it
14.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 1 synthesis or guideline pooled it, 121 citations in OpenAlex.

  1. Have Deaths of Despair Risen during the COVID-19 Pandemic? A Systematic Review.International journal of environmental research and public health · 2022
    Pooled it
  2. The Fast Track intervention's impact on behaviors of despair in adolescence and young adulthood.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. The Role of Race in Deaths of Despair in Brazil: Is it a White People Problem?Journal of racial and ethnic health disparities · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Observational
  13. The Role of Despair in Predicting Self-Destructive Behaviors.Population research and policy review · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Lilly ShanahanLilly Shanahan and Annekatrin Steinhoff are with the Jacobs Center for Productive Youth Development, University of Zurich, Zurich, Switzerland. Sherika N. Hill and E. Jane Costello are with the Department of Psychiatry, Duke University Medical Center, Durham, NC. Lauren M. Gaydosh is with the Center for Medicine, Health, and Society, Vanderbilt University, Nashville, TN. Kenneth A. Dodge is with the Center for Child and Family Policy, Duke University, Durham. Kathleen Mullan Harris is with the Carolina Population Center, University of North Carolina at Chapel Hill. William E. Copeland is with the Vermont Center for Children, Youth and Families, University of Vermont Medical Center, Burlington.
Sherika N HillLilly Shanahan and Annekatrin Steinhoff are with the Jacobs Center for Productive Youth Development, University of Zurich, Zurich, Switzerland. Sherika N. Hill and E. Jane Costello are with the Department of Psychiatry, Duke University Medical Center, Durham, NC. Lauren M. Gaydosh is with the Center for Medicine, Health, and Society, Vanderbilt University, Nashville, TN. Kenneth A. Dodge is with the Center for Child and Family Policy, Duke University, Durham. Kathleen Mullan Harris is with the Carolina Population Center, University of North Carolina at Chapel Hill. William E. Copeland is with the Vermont Center for Children, Youth and Families, University of Vermont Medical Center, Burlington.
Lauren M GaydoshLilly Shanahan and Annekatrin Steinhoff are with the Jacobs Center for Productive Youth Development, University of Zurich, Zurich, Switzerland. Sherika N. Hill and E. Jane Costello are with the Department of Psychiatry, Duke University Medical Center, Durham, NC. Lauren M. Gaydosh is with the Center for Medicine, Health, and Society, Vanderbilt University, Nashville, TN. Kenneth A. Dodge is with the Center for Child and Family Policy, Duke University, Durham. Kathleen Mullan Harris is with the Carolina Population Center, University of North Carolina at Chapel Hill. William E. Copeland is with the Vermont Center for Children, Youth and Families, University of Vermont Medical Center, Burlington.
Annekatrin SteinhoffLilly Shanahan and Annekatrin Steinhoff are with the Jacobs Center for Productive Youth Development, University of Zurich, Zurich, Switzerland. Sherika N. Hill and E. Jane Costello are with the Department of Psychiatry, Duke University Medical Center, Durham, NC. Lauren M. Gaydosh is with the Center for Medicine, Health, and Society, Vanderbilt University, Nashville, TN. Kenneth A. Dodge is with the Center for Child and Family Policy, Duke University, Durham. Kathleen Mullan Harris is with the Carolina Population Center, University of North Carolina at Chapel Hill. William E. Copeland is with the Vermont Center for Children, Youth and Families, University of Vermont Medical Center, Burlington.
E Jane CostelloLilly Shanahan and Annekatrin Steinhoff are with the Jacobs Center for Productive Youth Development, University of Zurich, Zurich, Switzerland. Sherika N. Hill and E. Jane Costello are with the Department of Psychiatry, Duke University Medical Center, Durham, NC. Lauren M. Gaydosh is with the Center for Medicine, Health, and Society, Vanderbilt University, Nashville, TN. Kenneth A. Dodge is with the Center for Child and Family Policy, Duke University, Durham. Kathleen Mullan Harris is with the Carolina Population Center, University of North Carolina at Chapel Hill. William E. Copeland is with the Vermont Center for Children, Youth and Families, University of Vermont Medical Center, Burlington.
Kenneth A DodgeLilly Shanahan and Annekatrin Steinhoff are with the Jacobs Center for Productive Youth Development, University of Zurich, Zurich, Switzerland. Sherika N. Hill and E. Jane Costello are with the Department of Psychiatry, Duke University Medical Center, Durham, NC. Lauren M. Gaydosh is with the Center for Medicine, Health, and Society, Vanderbilt University, Nashville, TN. Kenneth A. Dodge is with the Center for Child and Family Policy, Duke University, Durham. Kathleen Mullan Harris is with the Carolina Population Center, University of North Carolina at Chapel Hill. William E. Copeland is with the Vermont Center for Children, Youth and Families, University of Vermont Medical Center, Burlington.
Kathleen Mullan HarrisLilly Shanahan and Annekatrin Steinhoff are with the Jacobs Center for Productive Youth Development, University of Zurich, Zurich, Switzerland. Sherika N. Hill and E. Jane Costello are with the Department of Psychiatry, Duke University Medical Center, Durham, NC. Lauren M. Gaydosh is with the Center for Medicine, Health, and Society, Vanderbilt University, Nashville, TN. Kenneth A. Dodge is with the Center for Child and Family Policy, Duke University, Durham. Kathleen Mullan Harris is with the Carolina Population Center, University of North Carolina at Chapel Hill. William E. Copeland is with the Vermont Center for Children, Youth and Families, University of Vermont Medical Center, Burlington.
William E CopelandLilly Shanahan and Annekatrin Steinhoff are with the Jacobs Center for Productive Youth Development, University of Zurich, Zurich, Switzerland. Sherika N. Hill and E. Jane Costello are with the Department of Psychiatry, Duke University Medical Center, Durham, NC. Lauren M. Gaydosh is with the Center for Medicine, Health, and Society, Vanderbilt University, Nashville, TN. Kenneth A. Dodge is with the Center for Child and Family Policy, Duke University, Durham. Kathleen Mullan Harris is with the Carolina Population Center, University of North Carolina at Chapel Hill. William E. Copeland is with the Vermont Center for Children, Youth and Families, University of Vermont Medical Center, Burlington.
Center for Child and Family Health · US

Funding

STALLARD Admin Supp: Predicting Future Care Needs and Costs for Individual Medicare Enrollees with Incident Suspected Alzheimer's DiseaseP30AG034424 · NIA · DUKE UNIVERSITY · PI SCOTT M. LYNCH · 2009 to 2026
$12.2M
Research Services CoreP2CHD050924 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN B GUZZO · 2015 to 2026
$9.6M
Intervention Impacts on Child Wellbeing and Parenting across GenerationsR01HD093651 · NICHD · DUKE UNIVERSITY · PI KENNETH A DODGE, Jennifer E Lansford · 2017 to 2026
$6.1M
Science CoreP2CHD065563 · NICHD · DUKE UNIVERSITY · PI James Moody · 2015 to 2026
$5.7M
Diseases of Despair in Young Adulthood: Risk, Resilience, and PreventionR01MH117559 · NIMH · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI COPELAND, WILLIAM · 2018 to 2021
$1.6M
Early Substance Use in Rural American Indian and White/Anglo YouthR01DA036523 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHANAHAN, LILLY · 2014 to 2016
$700k
Explanations of Racial Disparities in Active LifeR03HD050374 · NICHD · PRINCETON UNIVERSITY · PI LYNCH, SCOTT M · 2005 to 2006
$156k
NIA NIH HHS P30 AG034424NICHD NIH HHS P2C HD050924NICHD NIH HHS P2C HD065563NICHD NIH HHS R01 HD093651NICHD NIH HHS R03 HD050374NIDA NIH HHS R01 DA036523NIMH NIH HHS R01 MH117559
6 · The paper itself

Abstract

Two seemingly associated demographic trends have generated considerable interest: income stagnation and rising premature mortality from suicides, drug poisoning, and alcoholic liver disease among US non-Hispanic Whites with low education. Economists interpret these population-level trends to indicate that despair induced by financial stressors is a shared pathway to these causes of death. Although we now have the catchy term "deaths of despair," we have yet to study its central empirical claim: that conceptually defined and empirically assessed "despair" is indeed a common pathway to several causes of death. At the level of the person, despair consists of cognitive, emotional, behavioral, and biological domains. Despair can also permeate social relationships, networks, institutions, and communities. Extant longitudinal data sets feature repeated measures of despair-before, during, and after the Great Recession-offering resources to test the role that despair induced by economic decline plays in premature morbidity and mortality. Such tests must also focus on protective factors that could shield individuals.

Indexed as

MortalityPsychological DistressCause of DeathHumansIncomeLiver Diseases, AlcoholicPoisoningSuicideUnited States

Identifiers

PMID30998413
PMCPMC6506367
OpenAlexW2937948999

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.