Evidence map›Paper›PMID 30998366›Full record

ArticleOrganic letters2019

Synthesis of HDAC Substrate Peptidomimetic Inhibitors Using Fmoc Amino Acids Incorporating Zinc-Binding Groups.

Amit Mahindra, Christopher J Millard, Iona Black, Lewis J Archibald, John W R Schwabe, Andrew G Jamieson

Open access · hybridAbstract read
In one paragraph

Article in Organic letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Amit MahindraSchool of Chemistry , University of Glasgow , Joseph Black Building, University Avenue , Glasgow G12 8QQ , U.K.
Christopher J MillardLeicester Institute of Structural and Chemical Biology, Department of Molecular and Cell Biology , University of Leicester , Leicester LE1 7RH , U.K.
Iona BlackSchool of Chemistry , University of Glasgow , Joseph Black Building, University Avenue , Glasgow G12 8QQ , U.K.
Lewis J ArchibaldSchool of Chemistry , University of Glasgow , Joseph Black Building, University Avenue , Glasgow G12 8QQ , U.K.
John W R SchwabeLeicester Institute of Structural and Chemical Biology, Department of Molecular and Cell Biology , University of Leicester , Leicester LE1 7RH , U.K.
Andrew G JamiesonSchool of Chemistry , University of Glasgow , Joseph Black Building, University Avenue , Glasgow G12 8QQ , U.K.ORCID 0000-0003-1726-7353
University of Glasgow · GBUniversity of Leicester · GB

Funding

Wellcome Trust 100237/Z/12/Z
6 · The paper itself

Abstract

Syntheses of Fmoc amino acids having zinc-binding groups were prepared and incorporated into substrate inhibitor H3K27 peptides using Fmoc/

Indexed as

Amino AcidsChelating AgentsCoordination ComplexesFluorenesHistone Deacetylase InhibitorsNickelPeptidomimeticsSolid-Phase Synthesis TechniquesStereoisomerismZincAmino AcidsChelating AgentsCoordination ComplexesFluorenesHistone Deacetylase InhibitorsN(alpha)-fluorenylmethyloxycarbonylamino acidsNickelPeptidomimeticsZinc

Identifiers

PMID30998366
PMCPMC6503537
OpenAlexW2939953502

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.