Evidence map›Paper›PMID 30998240›Full record

Observational studyOphthalmic surgery, lasers & imaging retina2019

Early Diagnosis and Management of Aggressive Posterior Vitreoretinopathy Presenting in Premature Neonates.

Mrinali P Gupta, Yoshihiro Yonekawa, J Peter Campbell, Irene Rusu, Sarwar Zahid, Samir N Patel, Felix Chau, Karyn E Jonas, Erica Oltra, Anton Orlin and 6 more

Open access · greenAbstract readMulticenter StudyObservational Study
In one paragraph

Observational study in Ophthalmic surgery, lasers & imaging retina, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 9 institutions in 1 country.

Mrinali P Gupta
Yoshihiro Yonekawa
J Peter Campbell
Irene Rusu
Sarwar Zahid
Samir N Patel
Felix Chau
Karyn E Jonas
Erica Oltra
Anton Orlin
Jonathan Chang
Jason Horowitz
David H Abramson
Brian Marr
Antonio Capone
R V Paul Chan
Columbia University · USUniversity of Illinois Chicago · USAssociated Retinal Consultants · USOakland University · USCornell University · USHarvard University · USMemorial Sloan Kettering Cancer Center · USOregon Health & Science University · USWills Eye Hospital · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Wilmer Core Grant for Vision ResearchP30EY001765 · NEI · JOHNS HOPKINS UNIVERSITY · PI Jiang Qian · 1985 to 2026
$22.1M
Proteomics CoreP30EY010572 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI TED S ACOTT · 1995 to 2026
$19.4M
Translational Core for Therapeutic and Diagnostic DevelopmentP30EY001792 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MCANANY, JAMES JASON · 1985 to 2025
$14.8M
Clinical and Genetic Analysis of Retinopathy of PrematurityR01EY019474 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI CAMPBELL, JOHN PETER · 2010 to 2020
$7.0M
Mentored Vision Clinician-Scientist Program at OHSUK12EY027720 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI David Huang · 2018 to 2026
$2.2M
Clinical and genetic analysis of retinopathy of prematurityR01HD107493 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI CAMPBELL, JOHN PETER · 2021 to 2023
$1.8M
NCI NIH HHS P30 CA008748NEI NIH HHS K12 EY027720NEI NIH HHS P30 EY001765NEI NIH HHS P30 EY001792NEI NIH HHS P30 EY010572NEI NIH HHS R01 EY019474NICHD NIH HHS R01 HD107493
6 · The paper itself

Abstract

BACKGROUND AND

objectiveAggressive posterior vitreoretinopathy (APVR) manifests with a broad area of retinal avascularity, progressive neovascularization, and/or tractional retinal detachment during the neonatal period. PATIENTS AND

methodsA multicenter, retrospective, observational, consecutive case series study was performed to evaluate the retinal findings and structural retinal outcomes in patients treated for APVR within the first 3 months of life.

resultsThree premature neonates with a non-retinopathy of prematurity (ROP) APVR identified during routine ROP screening exams exhibited relatively severe, rapidly progressive retinal vascular abnormalities. Immediate laser photocoagulation of the avascular retina and vitrectomy for traction retinal detachment within several days to weeks improved or stabilized the retinal anatomy in all cases.

conclusionsThis series describes clinical features in APVR in premature infants and suggests that early diagnosis and intervention may mitigate the typical aggressive course and poor prognosis of this condition. [Ophthalmic Surg Lasers Imaging Retina. 2019;50:201-207.].

Indexed as

Early DiagnosisInfant, PrematureAngiogenesis InhibitorsDisease ManagementFemaleFluorescein AngiographyFundus OculiGestational AgeHumansInfant, NewbornIntravitreal InjectionsLaser TherapyMalePrognosisRetrospective StudiesVascular Endothelial Growth Factor AAngiogenesis InhibitorsVascular Endothelial Growth Factor A

Identifiers

PMID30998240
PMCPMC7864674
OpenAlexW2935937454

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.