Evidence map›Paper›PMID 30998239›Full record

ReviewEndocrinology2019

Transgenerational Effects of Endocrine-Disrupting Chemicals on Male and Female Reproduction.

Emily Brehm, Jodi A Flaws

Open access · bronzeAbstract readReview
In one paragraph

Review in Endocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed, 1 pooled it
9.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 1 synthesis or guideline pooled it, 168 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Ovarian toxic effects of micro- and nanoplastics (Review).Experimental and therapeutic medicine · 2026
    Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. UTERINE FIBROIDS.Physiological reviews · 2025
    Review
  16. Observational
  17. Article
  18. Article
  19. Article
  20. Article

19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Emily BrehmDepartment of Comparative Biosciences, University of Illinois, Urbana, Illinois 61802.
Jodi A FlawsDepartment of Comparative Biosciences, University of Illinois, Urbana, Illinois 61802.
University of Illinois Urbana-Champaign · US

Funding

Project 3: Endocrine Disruptors and Diet: Effects on the Developing Cortex P01ES022848 · NIEHS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI FIESE, BARBARA H · 2013 to 2018
$4.2M
Phthalates and Ovarian ToxicityR01ES028661 · NIEHS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI FLAWS, JODI A. · 2018 to 2022
$1.8M
NIEHS NIH HHS P01 ES022848NIEHS NIH HHS R01 ES028661
6 · The paper itself

Abstract

Endocrine-disrupting chemicals are known to interfere with normal reproductive function and hormone signaling. Phthalates, bisphenol A, pesticides, and environmental contaminants such as polychlorinated biphenyls and dioxins are known endocrine-disrupting chemicals that have been shown to negatively affect both male and female reproduction. Exposure to these chemicals occurs on a daily basis owing to these compounds being found in plastics, personal care products, and pesticides. Recently, studies have shown that these chemicals may cause transgenerational effects on reproduction in both males and females. This is of concern because exposure to these chemicals prenatally or during adult life can negatively impact the reproductive health of future generations. This mini-review summarizes the endocrine-disrupting chemicals that humans are exposed to on a daily basis and what is known about the transgenerational effects that these chemicals may have on male and female reproduction.

Indexed as

AnimalsBenzhydryl CompoundsBisphenol A CompoundsEndocrine DisruptorsEnvironmental ExposureEnvironmental PollutantsFemaleHumansMalePhenolsPhthalic AcidsPregnancyPrenatal Exposure Delayed EffectsReproductionBenzhydryl Compoundsbisphenol ABisphenol A CompoundsEndocrine DisruptorsEnvironmental PollutantsPhenolsphthalic acidPhthalic Acids

Identifiers

PMID30998239
PMCPMC6525581
OpenAlexW2937600593

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.