Observational studyThe Journal of frailty & aging2019
Psoas and Paraspinous Muscle Measurements on Computed Tomography Predict Mortality in European Americans with Type 2 Diabetes Mellitus.
Observational study in The Journal of frailty & aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 13 citations in OpenAlex.
- Automated Muscle Measurement on Chest CT Predicts All-Cause Mortality in Older Adults From the National Lung Screening Trial.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Trial
- Association of immune checkpoint inhibitors with muscle mass and density in patients with melanoma.The oncologist · 2026Article
- Paraspinous muscle sarcopenic indices for predicting mortality in patients undergoing hemodialysis.Renal failure · 2025Article
- Differential impacts of fat and muscle mass on cardiovascular and non-cardiovascular mortality in individuals with type 2 diabetes.Journal of cachexia, sarcopenia and muscle · 2024Article
- Assessment of Psoas Muscle Index in Middle-Aged Type 2 Diabetes Patients: Impact of Insulin Therapy on Sarcopenia.Tomography (Ann Arbor, Mich.) · 2024Article
- Factors influencing slippage after microsurgical single level lumbar spinal decompression surgery - Are the psoas and multifidus muscles involved?Acta neurochirurgica · 2024Article
- Clinical parameters correlated with the psoas muscle index in Japanese individuals with type 2 diabetes mellitus.Diabetology international · 2023Article
- Psoas muscle index and psoas muscle density as predictors of mortality in patients undergoing hemodialysis.Scientific reports · 2022Article
- Myosteatosis rather than sarcopenia associates with non-alcoholic steatohepatitis in non-alcoholic fatty liver disease preclinical models.Journal of cachexia, sarcopenia and muscle · 2021Article
- Muscle Mass Assessed by the D3-Creatine Dilution Method and Incident Self-reported Disability and Mortality in a Prospective Observational Study of Community-Dwelling Older Men.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Observational
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAppendicular skeletal muscle mass index and muscle attenuation (density) are negatively associated with mortality in European-derived populations.
objectivesThe present analyses assessed association between axial skeletal muscle density and muscle index with mortality in European Americans with type 2 diabetes mellitus (T2D).
designSingle-center observational study.
settingDiabetes Heart Study.
participants839 European Americans with T2D.
methodsComputed tomography-measured psoas and paraspinous muscle mass index (cross sectional area/height2) and radiographic density (Hounsfield Units) were assessed in all participants. A Cox proportional hazards model was computed. The fully-adjusted model included covariates age, sex, body mass index, smoking, alcohol use, diabetes duration, insulin use, hormone replacement therapy (women), prevalent cardiovascular disease (CVD), hypertension, and coronary artery calcified atherosclerotic plaque mass score. Deaths were recorded in the National Death Index data through December 31, 2015.
resultsParticipants included 428 women and 411 men with median (25th, 75th quartile) age 62.8 (56.1, 69.1) years and diabetes duration 8.0 (5.0, 14.0) years. After 11.9 (9.4, 13.3) years of follow-up, 314 (37.4%) of participants were deceased. In the fully-adjusted model, psoas muscle density (hazard ratio [HR] 0.81, p<0.001), psoas muscle index (HR 0.82, p=0.008), and paraspinous muscle density (HR 0.85, p=0.003) were inversely associated with mortality. Paraspinous muscle index was not significantly associated with mortality (HR 0.90, p=0.08). Results did not differ significantly between men and women.
conclusionsIn addition to established risk factors for mortality and CVD, higher psoas muscle index, psoas muscle density, and paraspinous muscle density were significantly associated with lower all-cause mortality in European Americans with T2D.
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