Evidence map›Paper›PMID 30997658›Full record

SynthesisJournal of cancer survivorship : research and practice2019

Reproductive outcomes following treatment for a gynecological cancer diagnosis: a systematic review.

Brigitte Gerstl, Elizabeth Sullivan, Marcus Vallejo, Jana Koch, Maximilian Johnson, Handan Wand, Kate Webber, Angela Ives, Antoinette Anazodo

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Journal of cancer survivorship : research and practice, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 24 citations in OpenAlex.

  1. Roles of Goserelin in Gynecological Disorders.Drug design, development and therapy · 2026
    Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Fertility preservation in women with early-stage gynecologic cancer: optimizing oncologic and reproductive outcomes.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2021
    Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 3 countries.

Brigitte GerstlDepartment of Biostatistics, The Kirby Institute, University of New South Wales, Sydney, NSW, Australia.
Elizabeth SullivanAustralian Centre for Public Health and Population Health Research, Faculty of Health, University of Technology Sydney, Sydney, NSW, Australia.
Marcus VallejoKids Cancer Centre, Sydney Children's Hospital, Sydney, NSW, 2031, Australia.
Jana KochDepartment of Epidemiology, Technical University of Munich, Munich, Germany.
Maximilian JohnsonBrighton and Sussex Medical School, Royal Sussex County Hospital, Brighton, UK.
Handan WandDepartment of Biostatistics, The Kirby Institute, University of New South Wales, Sydney, NSW, Australia.
Kate WebberNelune Comprehensive Cancer Centre, Prince of Wales Hospital, Sydney, NSW, Australia.
Angela IvesCancer and Palliative Care Research and Evaluation Unit, University of Western Australia, Crawley, WA, Australia.
Antoinette AnazodoKids Cancer Centre, Sydney Children's Hospital, Sydney, NSW, 2031, Australia. Antoinette.anazodo@health.nsw.gov.au.
Prince of Wales Hospital · AUSydney Children's Hospital · AURoyal Sussex County Hospital · GBTechnical University of Munich · DEUniversity of Technology Sydney · AUUniversity of Western Australia · AUUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeFertility treatments are available for women diagnosed with a gynecological malignancy, which is important for women who desire a biological family subsequent to treatment. The objective of this study was to report reproductive outcomes following fertility-sparing treatment for a gynaecological cancer.

methodsElectronic databases were searched to identify studies that reported on reproductive outcomes after treatment for a gynecological malignancy.

resultsIn total, 77 studies were included which reported on reproductive outcomes after treatment for cervical cancer, endometrial cancer, gestational trophoblastic disease, and ovarian cancer. The main treatments included vaginal or abdominal radical trachelectomy, progestin therapy, salpingo-oophorectomy, and chemotherapy. The mean age at diagnosis for the study population and at birth were 30.5 years and 30.3 years, respectively. There were 4749 pregnancies (42%) reported for the included studies, with a miscarriage rate of 15% and a medical termination rate of 5%. The live birth rate was 74% with a 10% preterm rate. IMPLICATIONS FOR CANCER SURVIVORS: Patients should be offered timely discussions, information, and counseling regarding the impact of gynecological cancer treatment on a patient's fertility. Furthermore, fertility-sparing strategies and fertility preservation should be discussed prior to starting treatment.

Indexed as

AdolescentAdultCancer SurvivorsFemaleFertilityFertility PreservationGenital Neoplasms, FemaleHumansMiddle AgedPregnancyPregnancy OutcomePrognosisReproductionTreatment OutcomeUterine Cervical NeoplasmsYoung AdultGynecological neoplasmsOncofertilityPregnancySurvivorsSystematic review

Identifiers

PMID30997658
OpenAlexW2939894162

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.