Evidence map›Paper›PMID 30997619›Full record

Trial reportObesity surgery2019

Comparative Effects of Medical Versus Surgical Weight Loss on Body Composition: a Pilot Randomized Trial.

Sanskriti Varma, Clare J Lee, Todd T Brown, Nisa M Maruthur, Michael Schweitzer, Thomas Magnuson, Ihab Kamel, Jeanne M Clark

Registry-linked trialAbstract readComparative StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Obesity surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01667783 (Improving Diabetes Through Lifestyle and Surgery Study), which is not on this map. Cited by 8 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 4 pooled it
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01667783 phase2 / phase3completednot on this map

Improving Diabetes Through Lifestyle and Surgery Study

TypeinterventionalSponsorJohns Hopkins UniversityRan2012 to 2015Enrolled15ConditionsObesity, Type 2 DiabetesArmsGastric Banding, Medical Weight Loss, Gastric Bypass
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 4 syntheses or guidelines pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Surgery for the treatment of obesity in children and adolescents.The Cochrane database of systematic reviews · 2022
    Pooled it
  4. Pooled it
  5. Review
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Sanskriti VarmaThe Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Clare J LeeDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. clee158@jhmi.edu.ORCID 0000-0002-0824-0207
Todd T BrownDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Nisa M MaruthurDivision of General Internal Medicine, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Michael SchweitzerDepartment of Surgery, The Johns Hopkins University, Baltimore, MD, USA.
Thomas MagnusonDepartment of Surgery, The Johns Hopkins University, Baltimore, MD, USA.
Ihab KamelDepartment of Radiology, The Johns Hopkins University, Baltimore, MD, USA.
Jeanne M ClarkDivision of General Internal Medicine, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Johns Hopkins University · US

Funding

Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Translational Research Enhancement CoreP30DK089502 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI DONOWITZ, MARK · 2011 to 2020
$12.0M
Mechanisms and Effectiveness of Weight Loss Methods on Diabetes and Sleep ApneaR01DK089557 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI BRANCATI, FREDERICK L, CLARK, JEANNE M · 2010 to 2012
$1.5M
Exploring Mechanisms of Changes in Glucose Homeostasis After Bariatric Surgery: Comparing Vertical Sleeve Gastrectomy and Roux-en-Y Gastric BypassK23DK107921 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI LEE, CLARE JUNG EUN · 2016 to 2018
$582k
NCATS NIH HHS UL1 TR001079NIDDK NIH HHS 1R01DK089557NIDDK NIH HHS 5KL2TR001077-02NIDDK NIH HHS DK089502-01NIDDK NIH HHS K23DK107921NIDDK NIH HHS P30 DK089502NIDDK NIH HHS R01 DK089557
6 · The paper itself

Abstract

objectiveBariatric surgery leads to more rapid and greater weight loss (WL) compared to medical weight loss (MWL), but the differences in body composition (BC) changes for these modalities remain unclear. Due to the known health risks associated with central adiposity, we compared the changes in regional distribution of fat mass (FM) and lean mass (LM) after surgical versus MWL.

methodsIn this 1:1:1 randomized trial among 15 persons with type 2 diabetes and body mass index (BMI) 30-39.9 kg/m

resultsTwelve female participants (75% African American) completed the study. Patient age, BMI, and baseline anthropometric characteristics were similar across study arms. AGB lost more LM (MWL - 5.2%, AGB - 10.3%, p = 0.021) and VAT (MWL + 10.9%, AGB - 28.0%, p = 0.049) than MWL. RYGB tended to lose more VAT (MWL +10.9%, RYGB - 20.2%, p = 0.077) than MWL. AGB tended to lose more LM than RYGB (AGB - 12.38%, RYGB - 7.29%, p = 0.15).

conclusionsAt similar WL, AGB lost more LM and VAT than MWL; RYGB similarly lost more VAT. Given the metabolic benefits of reducing VAT and retaining LM, larger studies should confirm the changes in BC after surgical versus medical WL. CLINICAL

trial registrationNCTDK089557 - ClinicalTrials.gov.

Indexed as

Caloric RestrictionAbsorptiometry, PhotonAdultBariatric SurgeryBody CompositionBody Mass IndexDiabetes Mellitus, Type 2ExerciseFemaleGastric BypassGastroplastyHumansIntra-Abdominal FatMaleMiddle AgedObesityBariatric surgeryBody compositionClinical trialWeight loss

Identifiers

PMID30997619
OpenAlexW2938766719

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.