Evidence map›Paper›PMID 30997558›Full record

ArticleHeart and vessels2019

Impact of neointimal tissue characterization and heterogeneity of bare-metal stents and drug-eluting stents on the time course after stent implantation evaluated by integrated backscatter intravascular ultrasound.

Takashi Yoshizane, Shinichiro Tanaka, Shintaro Abe, Takahiro Ueno, Yoshiaki Goto, Tai Kojima, Makoto Iwama, Masazumi Arai, Toshiyuki Noda, Masanori Kawasaki

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Heart and vessels, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Takashi YoshizaneDepartment of Cardiology, Gifu Prefectural General Medical Center, 4-6-1, Noishiki, Gifu, 500-8226, Gifu, Japan. takashiyoshizane@gmail.com.ORCID http://orcid.org/0000-0002-5266-4867
Shinichiro TanakaAsahi University Hospital, Gifu, Gifu, Japan.
Shintaro AbeDepartment of Cardiology, Gifu Prefectural General Medical Center, 4-6-1, Noishiki, Gifu, 500-8226, Gifu, Japan.
Takahiro UenoDepartment of Cardiology, Gifu Prefectural General Medical Center, 4-6-1, Noishiki, Gifu, 500-8226, Gifu, Japan.
Yoshiaki GotoDepartment of Cardiology, Gifu Prefectural General Medical Center, 4-6-1, Noishiki, Gifu, 500-8226, Gifu, Japan.
Tai KojimaDepartment of Cardiology, Gifu Prefectural General Medical Center, 4-6-1, Noishiki, Gifu, 500-8226, Gifu, Japan.
Makoto IwamaDepartment of Cardiology, Gifu Prefectural General Medical Center, 4-6-1, Noishiki, Gifu, 500-8226, Gifu, Japan.
Masazumi AraiDepartment of Cardiology, Gifu Prefectural General Medical Center, 4-6-1, Noishiki, Gifu, 500-8226, Gifu, Japan.
Toshiyuki NodaDepartment of Cardiology, Gifu Prefectural General Medical Center, 4-6-1, Noishiki, Gifu, 500-8226, Gifu, Japan.
Masanori KawasakiGifu University Graduate School of Medicine, Gifu, Gifu, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pathological studies have suggested the different process of in-stent restenosis (ISR) of bare-metal stents (BMS) and drug-eluting stents (DES). Here, we evaluated the components of neointimal tissue using integrated backscatter intravascular ultrasound (IB-IVUS) and focused on the time course after stent implantation and tissue signal distribution. We evaluated 125 lesions of 125 patients who underwent target lesion revascularization for ISR (BMS: n = 73, DES: n = 52). Volume analysis of a 4-mm length centered on a minimum lumen area in every 1-mm cross-sectional area was performed. For IB-IVUS analysis, color-coded maps were constructed from the default setting based on the integrated backscatter (IB) values (middle-IB value, green: fibrous and low-IB value, blue: lipid pool). For the neointimal tissue volume, we evaluated the ratios of the green (%G) and blue (%B) areas. Tissue signal distribution (TD) was also obtained from the default setting based on IB values in each pixel of IB-IVUS imaging. We compared values of neointimal tissues measured by IB-IVUS between the DES and BMS and time course. The observed period was longer after BMS implantation than after DES implantation (BMS: 2545 days, DES: 1233 days, p < 0.001). Overall, %G and %B were similar between the BMS and DES groups (%G: 55% and 51%, respectively, p = 0.10; %B: 36% and 38%, respectively, p = 0.51); however, TD was significantly higher in the DES group than in the BMS group (1091 vs. 1367, p < 0.001). TD in the DES group remained high during the follow-up periods. However, TD in the BMS group was low in the early phase and significantly increased over time (r = 0.56, p < 0.001). When analyzing the ISR within 2 years after stent implantation, the BMS was distinguished with a sensitivity of 66% and a specificity of 90% (cut-off value: TD = 1135, area under the curve 0.83, 95% confidence interval 0.74-0.92). TD could differentiate neointimal tissue after BMS implantation in the early phase. TD can be a useful index in the observation of neoatherosclerosis.

Indexed as

MetalsUltrasonography, InterventionalAgedAngioplasty, Balloon, CoronaryCoronary AngiographyCoronary RestenosisDrug-Eluting StentsFemaleHumansLinear ModelsMaleMiddle AgedNeointimaProsthesis DesignRetrospective StudiesTreatment OutcomeMetalsBare-metal stentDrug-eluting stentIntegrated backscatter intravascular ultrasoundNeoatherosclerosisTissue signal distribution

Identifiers

PMID30997558

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.