ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2019
Validation of distal radius failure load predictions by homogenized- and micro-finite element analyses based on second-generation high-resolution peripheral quantitative CT images.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05204836 (Altering Bone Microarchitecture and Mechanics by Off-label Pharmaceutical Intervention), which is not on this map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Altering Bone Microarchitecture and Mechanics by Off-label Pharmaceutical Intervention
Who cites it
27 citing papers in PubMed.
- Bone quality response to lifestyle intervention in older adults with obesity (LIMB-Q trial): a randomised controlled trial.The lancet. Healthy longevity · 2025Trial
- HR-pQCT measures of bone in autosomal dominant osteopetrosis highly correlate with fractures and inversely correlate with bone resorption markers.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026Article
- Associations of muscle strength and functional power with longitudinal change in HR-pQCT bone parameters: the Osteoporotic Fractures in Men (MrOS) Study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026Article
- Sex- and site-specific reference data for size-invariant properties using multi-stack HRpQCT.JBMR plus · 2026Article
- Association of the vitamin D metabolite ratio with bone turnover markers and changes in volumetric BMD.JBMR plus · 2026Article
- Central and peripheral areal BMD, bone microarchitecture, and strength after initiation of androgen deprivation therapy in men with prostate cancer: a two-year follow-up study.Frontiers in endocrinology · 2026Observational
- Fabric-elasticity relationships of femoral head trabecular bone are similar in Type 2 diabetes and non-diabetic individuals.Bone reports · 2025Article
- The impact of segmentation approach on HR-pQCT microarchitectural and biomechanical metrics depends on bone structure.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025Article
- Integrating deep learning and machine learning for improved CKD-related cortical bone assessment in HRpQCT images: A pilot study.Bone reports · 2025Article
- Primary Stability of Dental Implants in Human Jawbones: Experiments & FE Analyses.Clinical oral implants research · 2025Article
- The Bone, Exercise, Alendronate, and Caloric Restriction (BEACON) trial design and methods.Contemporary clinical trials · 2024Article
- Article
- Diabetes Risk Factors and Bone Microarchitecture as Assessed by High-Resolution Peripheral Quantitative Computed Tomography in Adults With Long-standing Type 1 Diabetes.Diabetes care · 2024Article
- Homogenized finite element analysis of distal tibia sections: Achievements and limitations.Bone reports · 2024Article
- Am I big boned? Bone length scaled reference data for HRpQCT measures of the radial and tibial diaphysis in White adults.Bone reports · 2024Article
- Detection of osteoporotic-related bone changes and prediction of distal radius strength using Raman spectra from excised human cadaver finger bones.Journal of biomechanics · 2023Article
- Personalized loading conditions for homogenized finite element analysis of the distal sections of the radius.Biomechanics and modeling in mechanobiology · 2023Article
- Automatic segmentation of trabecular and cortical compartments in HR-pQCT images using an embedding-predicting U-Net and morphological post-processing.Scientific reports · 2023Article
- HR-pQCT parameters of the distal radius correlate with the bending strength of the radial diaphysis.Bone · 2022Article
- Variations in Strain Distribution at Distal Radius under Different Loading Conditions.Life (Basel, Switzerland) · 2022Article
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Authors and funding
6 authors.
Funding
Abstract
This study developed a well-standardized and reproducible approach for micro-finite element (mFE) and homogenized-FE (hFE) analyses that can accurately predict the distal radius failure load using either mFE or hFE models when using the approaches and parameters developed in this study.
introductionMicro-FE analyses based on high-resolution peripheral quantitative CT (HR-pQCT) images are frequently used to predict distal radius failure load. With the introduction of a second-generation HR-pQCT device, however, the default modelling approach no longer provides accurate results. The aim of this study was to develop a well-standardized and reproducible approach for mFE and hFE analyses that can provide precise and accurate results for distal radius failure load predictions based on second-generation HR-pQCT images.
methodsSecond-generation HR-pQCT was used to scan the distal 20-mm section of 22 cadaver radii. The sections were excised and mechanically tested afterwards. For these sections, mFE and hFE models were made that were used to identify required material parameters by comparing predicted and measured results. Using these parameters, the models were cropped to represent the 10-mm region recommended for clinical studies to test their performance for failure load prediction.
resultsAfter identification of material parameters, the measured failure load of the 20-mm segments was in good agreement with the results of mFE models (R
conclusionsIt was concluded that it is possible to accurately predict the distal radius failure load using either mFE or hFE models when using the approaches and parameters developed in this study.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.