Evidence map›Paper›PMID 30997152›Full record

ArticleRMD open2019

MRI of skeletal muscles in patients with idiopathic inflammatory myopathies: characteristic findings and diagnostic performance in dermatomyositis.

Taro Ukichi, Ken Yoshida, Satoshi Matsushima, Go Kawakami, Kentaro Noda, Kazuhiro Furuya, Daitaro Kurosaka

Open access · goldAbstract read
In one paragraph

Article in RMD open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.

  1. Guideline
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Observational
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Taro UkichiDivision of Rheumatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.ORCID 0000-0002-7292-4910
Ken YoshidaDivision of Rheumatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
Satoshi MatsushimaDepartment of Radiology, The Jikei University School of Medicine, Tokyo, Japan.
Go KawakamiDepartment of Radiology, The Jikei University School of Medicine, Tokyo, Japan.
Kentaro NodaDivision of Rheumatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
Kazuhiro FuruyaDivision of Rheumatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
Daitaro KurosakaDivision of Rheumatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
Jikei University School of Medicine · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To define the characteristic findings on MRI of skeletal muscles in patients with dermatomyositis (DM) relative to those in patients with other idiopathic inflammatory myopathies (IIMs) and to assess their diagnostic performance in DM. Methods: Thirty-six patients with DM, 17 patients with amyopathic DM, 19 patients with polymyositis and 16 patients with non-IIM classified by the 2017 European League Against Rheumatism/American College of Rheumatology criteria were included in this study. The following MRI findings (short-tau inversion recovery [STIR] and gadolinium-enhanced fat-suppressed T1-weighted imaging [Gd-T1WI]) for proximal limb muscles were compared between the disease groups and between myositis-specific autoantibodies/myositis-associated autoantibodies (MSAs/MAAs)-positive and MSAs/MAAs-negative groups: structures with high signal intensity (HSI) (subcutaneous, fascia, muscle); distributions of HSI areas in muscle (diffuse, patchy, peripheral) and patterns of HSI in muscle (honeycomb, foggy, strong HSI). Univariate, multivariate and receiver-operating characteristic [ROC] analyses were performed to assess the diagnostic performance of MRI in DM. Results: The characteristic MRI findings in patients with DM were subcutaneous HSI, fascial HSI, peripheral distribution and honeycomb pattern. The MRI findings in the MSAs/MAAs-positive group included more frequent fascial HSI but less frequent foggy pattern compared with the MSAs/MAAs-negative group. Likelihood of DM score ≥ 3 (obtained by counting the number of characteristic MRI findings in patients with DM) showed good diagnostic performance in DM (STIR: sensitivity 72.2%, specificity 88.5%, area under ROC curve [AUC] 84.9%; Gd-T1WI: sensitivity 81.2%, specificity 91.5%, AUC 89.9%). Conclusion: The characteristic MRI findings of skeletal muscles can predict patients with DM as well as patients with MSAs/MAAs.

Indexed as

Magnetic Resonance ImagingAdultAgedBiomarkersBiopsyDermatomyositisDiagnosis, DifferentialFemaleHumansImage Processing, Computer-AssistedMaleMiddle AgedMuscle, SkeletalMyositisPrognosisReproducibility of ResultsBiomarkersautoantibodiesautoimmune diseasesdermatomyositisMRIpolymyositis

Identifiers

PMID30997152
PMCPMC6443133
OpenAlexW2928696790

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.