ArticleChemical science2019
Catalytic β C-H amination
Article in Chemical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 80 citations in OpenAlex.
- Merging Double Hydrogen Atom Transfer and Stepwise Proton-Coupled Electron Transfer for γ‑C-H Hydrazination of Alcohols.JACS Au · 2026Article
- Carbon-Atom Scavengers Enable Divergent, Selective Carbon Deletion of Azaarenes.Journal of the American Chemical Society · 2025Article
- Recent Advances in Iodine-Mediated Radical Reactions.Advanced synthesis & catalysis · 2025Article
- Recent Progress in Synthetic Applications of Hypervalent Iodine(III) Reagents.Chemical reviews · 2024Review
- Strategies for AccessingMolecules (Basel, Switzerland) · 2024Review
- Recent advances in visible light-induced C(Nature reviews. Chemistry · 2022Article
- γ C-H Functionalization of Amines via Triple H-Atom Transfer of a Vinyl Sulfonyl Radical Chaperone.Journal of the American Chemical Society · 2022Article
- δ-C-H Halogenation Reactions Enabled by a Nitrogen-Centered Radical Precursor.Organic letters · 2022Article
- Article
- Silver-Catalyzed Enantioselective Sulfimidation Mediated by Hydrogen Bonding Interactions.Angewandte Chemie (International ed. in English) · 2021Article
- Regioselective Radical Amino-Functionalizations of Allyl Alcohols via Dual Catalytic Cross-Coupling.ACS catalysis · 2021Article
- Recent Advances in Rapid Synthesis of Non-proteinogenic Amino Acids from Proteinogenic Amino Acids Derivatives via Direct Photo-Mediated C-H Functionalization.Molecules (Basel, Switzerland) · 2020Review
- Visible-Light-Induced Palladium-Catalyzed Generation of Aryl Radicals from Aryl Triflates.Angewandte Chemie (International ed. in English) · 2020Article
- Visible-light promoted regioselective amination and alkylation of remote C(spNature communications · 2020Article
- Article
- Radical cascade synthesis of azolesChemical science · 2020Article
- A general method for site-selective CspChemical science · 2019Article
- Development of an Imine Chaperone for Selective C-H Functionalization of Alcohols via Radical Relay.The Journal of organic chemistry · 2019Article
- Practical, metal-free remote heteroarylation of amidesChemical science · 2019Article
- Transition-Metal- and Light-Free Directed Amination of Remote Unactivated C(spJournal of the American Chemical Society · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The first catalytic strategy to harness imidate radicals for C-H functionalization has been developed. This iodine-catalyzed approach enables β C-H amination of alcohols by an imidate-mediated radical relay. In contrast to our first-generation, (super)stoichiometric protocol, this catalytic method enables faster and more efficient reactivity. Furthermore, lower oxidant concentration affords broader functional group tolerance, including alkenes, alkynes, alcohols, carbonyls, and heteroarenes. Mechanistic experiments interrogating the electronic nature of the key 1,5 H-atom transfer event are included, as well as probes for chemo-, regio-, and stereo-selectivity.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.