Evidence map›Paper›PMID 30996975›Full record

ArticleChemical science2019

Hollow nanoreactors for Pd-catalyzed Suzuki-Miyaura coupling and

Paolo Destito, Ana Sousa-Castillo, José R Couceiro, Fernando López, Miguel A Correa-Duarte, José L Mascareñas

Abstract read
In one paragraph

Article in Chemical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

  1. Article
  2. Exploring New Bioorthogonal Catalysts: Scaffold Diversity in Catalysis for Chemical Biology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  3. Article
  4. Article
  5. Modular Fabrication of Bioorthogonal Nanozymes for Biomedical Applications.Advanced materials (Deerfield Beach, Fla.) · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Paolo DestitoCentro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS) , Departamento de Química Orgánica , Universidad de Santiago de Compostela , 15782 , Santiago de Compostela , Spain . Email: joseluis.mascarenas@usc.es.ORCID 0000-0001-7230-8619
Ana Sousa-CastilloDepartment of Physical Chemistry , Center for Biomedical Research (CINBIO) , Southern Galicia Institute of Health Research (IISGS) , Biomedical Research Networking Center for Mental Health (CIBERSAM) , Universidade de Vigo , 36310 Vigo , Spain . Email: macorrea@uvigo.es.ORCID 0000-0001-7811-0646
José R CouceiroCentro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS) , Departamento de Química Orgánica , Universidad de Santiago de Compostela , 15782 , Santiago de Compostela , Spain . Email: joseluis.mascarenas@usc.es.ORCID 0000-0002-5742-1071
Fernando LópezCentro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS) , Departamento de Química Orgánica , Universidad de Santiago de Compostela , 15782 , Santiago de Compostela , Spain . Email: joseluis.mascarenas@usc.es.ORCID 0000-0002-0235-6858
Miguel A Correa-DuarteDepartment of Physical Chemistry , Center for Biomedical Research (CINBIO) , Southern Galicia Institute of Health Research (IISGS) , Biomedical Research Networking Center for Mental Health (CIBERSAM) , Universidade de Vigo , 36310 Vigo , Spain . Email: macorrea@uvigo.es.ORCID 0000-0003-1950-1414
José L MascareñasCentro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS) , Departamento de Química Orgánica , Universidad de Santiago de Compostela , 15782 , Santiago de Compostela , Spain . Email: joseluis.mascarenas@usc.es.ORCID 0000-0002-7789-700X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We describe the fabrication of hollow microspheres consisting of mesoporous silica nanoshells decorated with an inner layer of palladium nanoparticles and their use as Pd-nanoreactors in aqueous media. These palladium-equipped capsules can be used to promote the uncaging of propargyl-protected phenols, as well as Suzuki-Miyaura cross-coupling, in water and at physiologically compatible temperatures. Importantly, the depropargylation reaction can be accomplished in a bioorthogonal manner in the presence of relatively high concentrations of biomolecular components and even in the presence of mammalian cells.

Identifiers

PMID30996975
PMCPMC6419927

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.