Evidence map›Paper›PMID 30996966›Full record

ArticleChemical science2019

Functional black phosphorus nanosheets for mitochondria-targeting photothermal/photodynamic synergistic cancer therapy.

Xiaoyan Yang, Dongya Wang, Jiawei Zhu, Lei Xue, Changjin Ou, Wenjun Wang, Min Lu, Xuejiao Song, Xiaochen Dong

Open access · diamondAbstract read
In one paragraph

Article in Chemical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
13.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 177 citations in OpenAlex.

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  15. Black Phosphorus - A Rising Star in the Antibacterial Materials.International journal of nanomedicine · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Xiaoyan YangKey Laboratory of Flexible Electronics (KLOFE) , Institute of Advanced Materials (IAM) , School of Physical and Mathematical Science , Nanjing Tech University (NanjingTech) , 30 South Puzhu Road , Nanjing 211800 , China . Email: iamxcdong@njtech.edu.cn ; Email: iammlv@njtech.edu.cn ; Email: songxuejiao8888@163.com.
Dongya WangKey Laboratory of Flexible Electronics (KLOFE) , Institute of Advanced Materials (IAM) , School of Physical and Mathematical Science , Nanjing Tech University (NanjingTech) , 30 South Puzhu Road , Nanjing 211800 , China . Email: iamxcdong@njtech.edu.cn ; Email: iammlv@njtech.edu.cn ; Email: songxuejiao8888@163.com.
Jiawei ZhuKey Laboratory of Flexible Electronics (KLOFE) , Institute of Advanced Materials (IAM) , School of Physical and Mathematical Science , Nanjing Tech University (NanjingTech) , 30 South Puzhu Road , Nanjing 211800 , China . Email: iamxcdong@njtech.edu.cn ; Email: iammlv@njtech.edu.cn ; Email: songxuejiao8888@163.com.
Lei XueKey Laboratory of Flexible Electronics (KLOFE) , Institute of Advanced Materials (IAM) , School of Physical and Mathematical Science , Nanjing Tech University (NanjingTech) , 30 South Puzhu Road , Nanjing 211800 , China . Email: iamxcdong@njtech.edu.cn ; Email: iammlv@njtech.edu.cn ; Email: songxuejiao8888@163.com.
Changjin OuKey Laboratory of Flexible Electronics (KLOFE) , Institute of Advanced Materials (IAM) , School of Physical and Mathematical Science , Nanjing Tech University (NanjingTech) , 30 South Puzhu Road , Nanjing 211800 , China . Email: iamxcdong@njtech.edu.cn ; Email: iammlv@njtech.edu.cn ; Email: songxuejiao8888@163.com.
Wenjun WangSchool of Physical Science and Information Technology , Liaocheng University , Liaocheng 252059 , China.
Min LuKey Laboratory of Flexible Electronics (KLOFE) , Institute of Advanced Materials (IAM) , School of Physical and Mathematical Science , Nanjing Tech University (NanjingTech) , 30 South Puzhu Road , Nanjing 211800 , China . Email: iamxcdong@njtech.edu.cn ; Email: iammlv@njtech.edu.cn ; Email: songxuejiao8888@163.com.
Xuejiao SongKey Laboratory of Flexible Electronics (KLOFE) , Institute of Advanced Materials (IAM) , School of Physical and Mathematical Science , Nanjing Tech University (NanjingTech) , 30 South Puzhu Road , Nanjing 211800 , China . Email: iamxcdong@njtech.edu.cn ; Email: iammlv@njtech.edu.cn ; Email: songxuejiao8888@163.com.
Xiaochen DongKey Laboratory of Flexible Electronics (KLOFE) , Institute of Advanced Materials (IAM) , School of Physical and Mathematical Science , Nanjing Tech University (NanjingTech) , 30 South Puzhu Road , Nanjing 211800 , China . Email: iamxcdong@njtech.edu.cn ; Email: iammlv@njtech.edu.cn ; Email: songxuejiao8888@163.com.ORCID 0000-0003-4837-9059
Nanjing Tech University · CNLiaocheng University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Organelle-targeting nanosystems are envisioned as promising tools for phototherapy, which can generate heat or reactive oxygen species (ROS) induced cytotoxicity in the targeted location but leave the surrounding biological tissues undamaged. In this work, an imaging-guided mitochondria-targeting photothermal/photodynamic nanosystem has been developed on the basis of functionalized black phosphorus (BP) nanosheets (NSs). In the nanosystem, BP NSs are coated with polydopamine (PDA) and then covalently linked with both chlorin e6 (Ce6) and triphenyl phosphonium (TPP) through carbodiimide reaction between the amino group and the carboxyl group, forming BP@PDA-Ce6&TPP NSs. Due to the strong absorbance of BP@PDA in the near-infrared region and the highly efficient ROS generation of Ce6, the as-prepared nanosystem with mitochondria-targeting capacity (TPP moiety) shows remarkably enhanced efficiency in cancer cell killing. Combined photothermal and photodynamic therapy is implemented and monitored by

Identifiers

PMID30996966
PMCPMC6446962
OpenAlexW2916762679

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.