ArticleChemical science2019
Copper-catalyzed 1,4-alkylarylation of 1,3-enynes with masked alkyl electrophiles.
Article in Chemical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Dealkenylative Functionalizations: Conversion of Alkene C(spSynthesis · 2024Article
- Remote Radical 1,3-, 1,4-, 1,5-, 1,6- and 1,7-Difunctionalization Reactions.Molecules (Basel, Switzerland) · 2023Review
- When all C-C breaks LO-Ose.Trends in chemistry · 2023Article
- Radical transformations for allene synthesis.Chemical science · 2022Review
- NHC and visible light-mediated photoredox co-catalyzed 1,4-sulfonylacylation of 1,3-enynes for tetrasubstituted allenyl ketones.Chemical science · 2022Article
- Palladium-catalyzed selective C-C bond cleavage and stereoselective alkenylation between cyclopropanol and 1,3-diyne: one-step synthesis of diverse conjugated enynes.Chemical science · 2022Article
- Regiodivergent sulfonylarylation of 1,3-enynesChemical science · 2021Article
- Decarboxylative 1,4-carbocyanation of 1,3-enynes to access tetra-substituted allenesChemical science · 2021Article
- Deciphering the Chameleonic Chemistry of Allenols: Breaking the Taboo of a Onetime Esoteric Functionality.Chemical reviews · 2021Article
- Copper-catalyzed functionalization of enynes.Chemical science · 2020Review
- Tailored Palladium Catalysts for Selective Synthesis of Conjugated Enynes by Monocarbonylation of 1,3-Diynes.Angewandte Chemie (International ed. in English) · 2020Article
- Synthesis of difluoromethylated allenes through trifunctionalization of 1,3-enynes.Nature communications · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Classical 1,4-dicarbofunctionalization of 1,3-enynes employs organometallic reagents as nucleophiles to initiate the reaction. We report a copper-catalyzed 1,4-alkylarylation of 1,3-enynes with alkyl diacyl peroxides as masked alkyl electrophiles and aryl boronic acids as nucleophiles, selectively affording structurally diversified tetrasubstituted allenes under mild conditions. Mechanistic studies suggest that an allenyl radical might be involved.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.