Evidence map›Paper›PMID 30996940›Full record

ArticleChemical science2019

Facile synthesis of AIEgens with wide color tunability for cellular imaging and therapy.

Wenhan Xu, Michelle M S Lee, Zhihan Zhang, Herman H Y Sung, Ian D Williams, Ryan T K Kwok, Jacky W Y Lam, Dong Wang, Ben Zhong Tang

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
8.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 147 citations in OpenAlex.

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  13. Intracellular Ruthenium-Promoted (2+2+2) Cycloadditions.Angewandte Chemie (International ed. in English) · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 3 countries.

Wenhan XuHong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction , Department of Chemistry , Institute of Molecular Functional Materials , State Key Laboratory of Neuroscience , Division of Biomedical Engineering , Division of Life Science , The Hong Kong University of Science and Technology , Clear Water Bay , Kowloon , Hong Kong , China . Email: tangbenz@ust.hk.ORCID 0000-0002-7572-616X
Michelle M S LeeHong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction , Department of Chemistry , Institute of Molecular Functional Materials , State Key Laboratory of Neuroscience , Division of Biomedical Engineering , Division of Life Science , The Hong Kong University of Science and Technology , Clear Water Bay , Kowloon , Hong Kong , China . Email: tangbenz@ust.hk.ORCID 0000-0002-8389-8500
Zhihan ZhangHong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction , Department of Chemistry , Institute of Molecular Functional Materials , State Key Laboratory of Neuroscience , Division of Biomedical Engineering , Division of Life Science , The Hong Kong University of Science and Technology , Clear Water Bay , Kowloon , Hong Kong , China . Email: tangbenz@ust.hk.ORCID 0000-0002-1758-3914
Herman H Y SungHong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction , Department of Chemistry , Institute of Molecular Functional Materials , State Key Laboratory of Neuroscience , Division of Biomedical Engineering , Division of Life Science , The Hong Kong University of Science and Technology , Clear Water Bay , Kowloon , Hong Kong , China . Email: tangbenz@ust.hk.
Ian D WilliamsHong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction , Department of Chemistry , Institute of Molecular Functional Materials , State Key Laboratory of Neuroscience , Division of Biomedical Engineering , Division of Life Science , The Hong Kong University of Science and Technology , Clear Water Bay , Kowloon , Hong Kong , China . Email: tangbenz@ust.hk.ORCID 0000-0001-8743-401X
Ryan T K KwokHong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction , Department of Chemistry , Institute of Molecular Functional Materials , State Key Laboratory of Neuroscience , Division of Biomedical Engineering , Division of Life Science , The Hong Kong University of Science and Technology , Clear Water Bay , Kowloon , Hong Kong , China . Email: tangbenz@ust.hk.ORCID 0000-0002-6866-3877
Jacky W Y LamHong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction , Department of Chemistry , Institute of Molecular Functional Materials , State Key Laboratory of Neuroscience , Division of Biomedical Engineering , Division of Life Science , The Hong Kong University of Science and Technology , Clear Water Bay , Kowloon , Hong Kong , China . Email: tangbenz@ust.hk.ORCID 0000-0001-5754-1703
Dong WangCenter for AIE Research , College of Materials Science and Engineering , Shenzhen University , Shenzhen 518060 , China . Email: wangd@szu.edu.cn.ORCID 0000-0001-5137-0771
Ben Zhong TangHong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction , Department of Chemistry , Institute of Molecular Functional Materials , State Key Laboratory of Neuroscience , Division of Biomedical Engineering , Division of Life Science , The Hong Kong University of Science and Technology , Clear Water Bay , Kowloon , Hong Kong , China . Email: tangbenz@ust.hk.ORCID 0000-0002-0293-964X
Hong Kong University of Science and Technology · HKShenzhen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Luminogens with aggregation-induced emission (AIE) characteristics are nowadays undergoing explosive development in the fields of imaging, process visualization, diagnosis and therapy. However, exploration of an AIE luminogen (AIEgen) system allowing for extremely wide color tunability remains challenging. In this contribution, the facile synthesis of triphenylamine (TPA)-thiophene building block-based AIEgens having tunable maximum emission wavelengths covering violet, blue, green, yellow, orange, red, deep red and NIR regions is reported. The obtained AIEgens can be utilized as extraordinary fluorescent probes for lipid droplet (LD)-specific cell imaging and cell fusion assessment, showing excellent image contrast to the cell background and high photostability, as well as satisfactory visualization outcomes. Interestingly, quantitative evaluation of the phototherapy effect demonstrates that one of these presented AIEgens, namely TTNIR, performs well as a photosensitizer for photodynamic ablation of cancer cells upon white light irradiation. This study thus provides useful insights into rational design of fluorescence systems for widely tuning emission colors with high brightness, and remarkably extends the applications of AIEgens.

Identifiers

PMID30996940
PMCPMC6432335
OpenAlexW2915356222

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.