Evidence map›Paper›PMID 30996912›Full record

ArticleChemical science2019

Development of a dual-functional conjugate of antigenic peptide and Fc-III mimetics (DCAF) for targeted antibody blocking.

Lin Zhang, Hao Shen, Yiyi Gong, Xiaojing Pang, Meiqi Yi, Lin Guo, Jin Li, Sam Arroyo, Xin Lu, Sergey Ovchinnikov and 5 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 4 countries.

Lin ZhangMOE Key Laboratory of Bioinformatics , Center for Synthetic and Systems Biology , School of Life Sciences , Tsinghua University , Beijing , China . Email: dht@mail.tsinghua.edu.cn.
Hao ShenInstitute for Protein Design , Department of Biochemistry , University of Washington , Seattle , WA , USA.
Yiyi GongCentral Research Laboratory , Peking Union Medical College Hospital , Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China.
Xiaojing PangTsinghua-Peking Center for Life Sciences , School of Medicine , Tsinghua University , Beijing , China.
Meiqi YiMOE Key Laboratory of Bioinformatics , Center for Synthetic and Systems Biology , School of Life Sciences , Tsinghua University , Beijing , China . Email: dht@mail.tsinghua.edu.cn.
Lin GuoMOE Key Laboratory of Bioinformatics , Center for Synthetic and Systems Biology , School of Life Sciences , Tsinghua University , Beijing , China . Email: dht@mail.tsinghua.edu.cn.
Jin LiMOE Key Laboratory of Bioinformatics , Center for Synthetic and Systems Biology , School of Life Sciences , Tsinghua University , Beijing , China . Email: dht@mail.tsinghua.edu.cn.
Sam ArroyoDepartment of Biological Sciences , University of Notre Dame , South Bend , IN , USA.
Xin LuDepartment of Biological Sciences , University of Notre Dame , South Bend , IN , USA.
Sergey OvchinnikovInstitute for Protein Design , Department of Biochemistry , University of Washington , Seattle , WA , USA.
Gong ChengTsinghua-Peking Center for Life Sciences , School of Medicine , Tsinghua University , Beijing , China.
Xudong LiuCentral Research Laboratory , Peking Union Medical College Hospital , Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China.
Xu JiangCentral Research Laboratory , Peking Union Medical College Hospital , Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China.
Shan FengMass Spectrometry Facility , Westlake Lake University , Hangzhou , Zhejiang Province , China . Email: fengshan@westlake.edu.cn.
Haiteng DengMOE Key Laboratory of Bioinformatics , Center for Synthetic and Systems Biology , School of Life Sciences , Tsinghua University , Beijing , China . Email: dht@mail.tsinghua.edu.cn.ORCID 0000-0002-2545-9841
Institut de Biologie systémique et synthétique · FRChinese Academy of Medical Sciences & Peking Union Medical College · CNKing Center · USUniversity of Notre Dame · USUniversity of Washington · USWestlake University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Targeted antibody blocking enables characterization of binding sites on immunoglobulin G (IgG), and can efficiently eliminate harmful antibodies from organisms. In this report, we present a novel peptide-denoted as a dual-functional conjugate of antigenic peptide and Fc-III mimetics (DCAF)-for targeted blocking of antibodies. Synthesis of DCAF was achieved by native chemical ligation, and the molecule consists of three functional parts: a specific antigenic peptide, a linker and the Fc-III mimetic peptide, which has a high affinity toward the Fc region of IgG molecules. We demonstrate that DCAF binds the cognate antibody with high selectivity by simultaneously binding to the Fab and Fc regions of IgG. Animal experiments revealed that DCAF molecules diminish the antibody-dependent enhancement effect in a dengue virus infection model, and rescue the acetylcholine receptor by inhibiting the complement cascade in a

Identifiers

PMID30996912
PMCPMC6429600
OpenAlexW2911470604

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.