Evidence map›Paper›PMID 30996885›Full record

ArticleChemical science2019

Comparative genome mining and heterologous expression of an orphan NRPS gene cluster direct the production of ashimides.

Jing Shi, Ying Jie Zeng, Bo Zhang, Fen Li Shao, Yan Chi Chen, Xiang Xu, Yang Sun, Qiang Xu, Ren Xiang Tan, Hui Ming Ge

Open access · diamondAbstract read
In one paragraph

Article in Chemical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
5.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 56 citations in OpenAlex.

  1. Biodiversity and Natural Product Potential of Indonesian Actinomycetes.Journal of microbiology and biotechnology · 2026
    Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Bacterial natural product discovery by heterologous expression.Journal of industrial microbiology & biotechnology · 2023
    Review
  9. Naturally Occurring Organohalogen Compounds-A Comprehensive Review.Progress in the chemistry of organic natural products · 2023
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Pyridoxal-5'-phosphate-dependent bifunctional enzyme catalyzed biosynthesis of indolizidine alkaloids in fungi.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 3 countries.

Jing ShiState Key Laboratory of Pharmaceutical Biotechnology , Institute of Functional Biomolecules , School of Life Sciences , Nanjing University , 210023 , China . Email: rxtan@nju.edu.cn ; Email: hmge@nju.edu.cn.
Ying Jie ZengState Key Laboratory of Pharmaceutical Biotechnology , Institute of Functional Biomolecules , School of Life Sciences , Nanjing University , 210023 , China . Email: rxtan@nju.edu.cn ; Email: hmge@nju.edu.cn.
Bo ZhangState Key Laboratory of Pharmaceutical Biotechnology , Institute of Functional Biomolecules , School of Life Sciences , Nanjing University , 210023 , China . Email: rxtan@nju.edu.cn ; Email: hmge@nju.edu.cn.
Fen Li ShaoState Key Laboratory of Pharmaceutical Biotechnology , Institute of Functional Biomolecules , School of Life Sciences , Nanjing University , 210023 , China . Email: rxtan@nju.edu.cn ; Email: hmge@nju.edu.cn.
Yan Chi ChenState Key Laboratory of Pharmaceutical Biotechnology , Institute of Functional Biomolecules , School of Life Sciences , Nanjing University , 210023 , China . Email: rxtan@nju.edu.cn ; Email: hmge@nju.edu.cn.
Xiang XuState Key Laboratory of Pharmaceutical Biotechnology , Institute of Functional Biomolecules , School of Life Sciences , Nanjing University , 210023 , China . Email: rxtan@nju.edu.cn ; Email: hmge@nju.edu.cn.
Yang SunState Key Laboratory of Pharmaceutical Biotechnology , Institute of Functional Biomolecules , School of Life Sciences , Nanjing University , 210023 , China . Email: rxtan@nju.edu.cn ; Email: hmge@nju.edu.cn.
Qiang XuState Key Laboratory of Pharmaceutical Biotechnology , Institute of Functional Biomolecules , School of Life Sciences , Nanjing University , 210023 , China . Email: rxtan@nju.edu.cn ; Email: hmge@nju.edu.cn.
Ren Xiang TanState Key Laboratory of Pharmaceutical Biotechnology , Institute of Functional Biomolecules , School of Life Sciences , Nanjing University , 210023 , China . Email: rxtan@nju.edu.cn ; Email: hmge@nju.edu.cn.ORCID 0000-0002-0218-307X
Hui Ming GeState Key Laboratory of Pharmaceutical Biotechnology , Institute of Functional Biomolecules , School of Life Sciences , Nanjing University , 210023 , China . Email: rxtan@nju.edu.cn ; Email: hmge@nju.edu.cn.ORCID 0000-0002-0468-808X
Pharmaceutical Biotechnology (Czechia) · CZNanjing University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ever-increasing bacterial genomic repositories reveal a great number of uncharacterized biosynthetic gene clusters, representing a tremendous resource for natural product discovery. Genome mining of the marine

Identifiers

PMID30996885
PMCPMC6427947
OpenAlexW2908988949

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.