Evidence map›Paper›PMID 30996830›Full record

ArticleIranian journal of microbiology2019

Vaccine potential of LenA and LcpA proteins of

Mehran Ghazali-Bina, Mohammad Reza Pourmand, Abbas Mirshafiey, Ronak Bakhtiari, Azad Khaledi, Hamid Kazemian, Davoud Afshar, Muhammad Ibrahim Getso, Saeid Eshraghi

Open access · diamondAbstract read
PubMed Full text at PMC
In one paragraph

Article in Iranian journal of microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Incorporation ofBiosafety and health · 2023
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Mehran Ghazali-BinaDepartment of Microbiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Mohammad Reza PourmandDepartment of Microbiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Abbas MirshafieyDepartment of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Ronak BakhtiariDepartment of Microbiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Azad KhalediInfectious Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran.
Hamid KazemianDepartment of Microbiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Davoud AfsharDepartment of Microbiology and Virology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
Muhammad Ibrahim GetsoDepartment of Medical Mycology, School of Public Health, Tehran University of Medical Sciences, Intenational College, Tehran, Iran.
Saeid EshraghiDepartment of Microbiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Tehran University of Medical Sciences · IRKashan University of Medical Sciences · IRZanjan University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesLeptospirosis is a zooanthroponosis caused by the genus of MATERIALS AND

methodsThe genes encoding these proteins were cloned into pGH cloning vector and then

resultsImmunized hamsters with rLenA-plus-rLTB, rLcpA-plus-rLTB and rLenA-plus-rLcpA-plus-rLTB proteins showed 60%, 74%, and 80% survival rates, respectively. A significant amount of interleukin-17 (IL-17), interleukin-4 (IL-4) and gamma interferon (IFNγ) cytokines were produced in immunized hamsters.

conclusionBased on our findings, rLcpA and rLenA proteins in combination with rLTB can protect the hamsters against

Indexed as

ImmunogenicityLeptospira interrogansRecombinant proteinsVaccine

Identifiers

PMID30996830
PMCPMC6462271
OpenAlexW2941175082

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.