Evidence map›Paper›PMID 30996822›Full record

ArticleComputational and structural biotechnology journal2019

Proteins with Evolutionarily Hypervariable Domains are Associated with Immune Response and Better Survival of Basal-like Breast Cancer Patients.

Shutan Xu, Yuan Feng, Shaying Zhao

Open access · goldAbstract read
In one paragraph

Article in Computational and structural biotechnology journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Pan-cancer analysis and oncogenic implications ofJournal of cell communication and signaling · 2025
    Article
  4. Pan-cancer analysis reveals the prognostic and immunomodulatory potential of super-enhancer-induced ANGPT2 and experimental validation in colorectal cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Article
  5. Bioinformatics insights intoFrontiers in cell and developmental biology · 2025
    Article
  6. TMPO-AS1-hsa-let-7b-5p-EZH2-RNA network predicts poor survival in basal-like breast cancer patients.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2025
    Article
  7. Article
  8. Gene Expression Dysregulation in Whole Blood of Patients withInternational journal of molecular sciences · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Science advances · 2023
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. DOT1L Is a Novel Cancer Stem Cell Target for Triple-Negative Breast Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Shutan XuDepartment of Biochemistry and Molecular Biology, Institute of Bioinformatics, University of Georgia, Athens, GA 30602-7229, USA.
Yuan FengDepartment of Biochemistry and Molecular Biology, Institute of Bioinformatics, University of Georgia, Athens, GA 30602-7229, USA.
Shaying ZhaoDepartment of Biochemistry and Molecular Biology, Institute of Bioinformatics, University of Georgia, Athens, GA 30602-7229, USA.
University of Georgia · US

Funding

Man's Best Friend for Driver-Passenger DistinctionR01CA182093 · NCI · UNIVERSITY OF GEORGIA · PI ZHAO, SHAYING · 2014 to 2018
$1.6M
NCI NIH HHS R01 CA182093
6 · The paper itself

Abstract

Maltase-glucoamylase (MGAM) and MGAM2 both belong to the glycoside hydrolase family 31. MGAM, a therapeutic target for type 2 diabetes, is α-1,4-glucosidase and expressed in the intestine to catalyze starch digestion. MGAM2, however, is largely uncharacterized. By investigating The Cancer Genome Atlas data, we found that among breast cancer subtypes

Indexed as

BLBCEHVImmune responseMGAMMGAM2Patient survivalPlacental-marsupial splitα-1,4-glucosidase

Identifiers

PMID30996822
PMCPMC6451114
OpenAlexW2925056816

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.