Evidence map›Paper›PMID 30996795›Full record

ArticleACS medicinal chemistry letters2019

Behind the Mirror: Chirality Tunes the Reactivity and Cytotoxicity of Chloropiperidines as Potential Anticancer Agents.

Caterina Carraro, Alexander Francke, Alice Sosic, Franziska Kohl, Tim Helbing, Michele De Franco, Daniele Fabris, Richard Göttlich, Barbara Gatto

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Caterina CarraroDepartment of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Francesco Marzolo 5, 35131 Padova, Italy.
Alexander FranckeInstitute of Organic Chemistry, Justus Liebig University Giessen, Heinrich-Buff-Ring 17, 35392 Giessen, Germany.
Alice SosicDepartment of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Francesco Marzolo 5, 35131 Padova, Italy.
Franziska KohlDepartment of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Francesco Marzolo 5, 35131 Padova, Italy.
Tim HelbingInstitute of Organic Chemistry, Justus Liebig University Giessen, Heinrich-Buff-Ring 17, 35392 Giessen, Germany.
Michele De FrancoDepartment of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Francesco Marzolo 5, 35131 Padova, Italy.
Daniele FabrisDepartments of Chemistry and Biological Sciences, University at Albany, State University of New York, 1400 Washington Avenue, Albany, New York 12222, United States.
Richard GöttlichInstitute of Organic Chemistry, Justus Liebig University Giessen, Heinrich-Buff-Ring 17, 35392 Giessen, Germany.
Barbara GattoDepartment of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Francesco Marzolo 5, 35131 Padova, Italy.

Funding

Structural determinants of HIV-1 5'-UTR riboswitch and NC actuation by MS3DR01GM064328 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI FABRIS, DANIELE · 2001 to 2013
$3.8M
Characterization of ncRNAs' post-transcriptional modifications by antisense affinity capture and MS analysisR01GM121844 · NIGMS · UNIVERSITY OF CONNECTICUT STORRS · PI FABRIS, DANIELE · 2017 to 2021
$1.6M
NIGMS NIH HHS R01 GM064328NIGMS NIH HHS R01 GM121844
6 · The paper itself

Abstract

The pressing demand for sustainable antitumor drugs prompted us to investigate 3-chloropiperidines as potential mustard-based anticancer agents. In this study, an explorative set of variously decorated monofunctional 3-chloropiperidines (M-CePs) was efficiently synthesized through a fast and affordable route providing high yields of pure racemates and enantiomers. Consistently with their reactivity, M-CePs were demonstrated to alkylate DNA

Identifiers

PMID30996795
PMCPMC6466835

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.