Evidence map›Paper›PMID 30996687›Full record

ArticleCancer cell international2019

Genetic variants in the circadian rhythm pathway as indicators of prostate cancer progression.

Chia-Cheng Yu, Lih-Chyang Chen, Chih-Yung Chiou, Yu-Jia Chang, Victor C Lin, Chao-Yuan Huang, I-Ling Lin, Ta-Yuan Chang, Te-Ling Lu, Cheng-Hsueh Lee and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cancer cell international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 37 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Circadian rhythm disruption and endocrine-related tumors.World journal of clinical oncology · 2024
    Review
  6. Natural Compounds for Preventing Age-Related Diseases and Cancers.International journal of molecular sciences · 2024
    Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Genetic Analysis Implicates Dysregulation ofInternational journal of environmental research and public health · 2022
    Article
  15. Article
  16. Journal of preventive medicine and hygiene · 2021
    Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 1 country.

Chia-Cheng Yu *1Division of Urology, Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, 813 Taiwan.
Lih-Chyang Chen *4Department of Medicine, Mackay Medical College, New Taipei City, 252 Taiwan.
Chih-Yung Chiou *5Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Taoyuan, 333 Taiwan.
Yu-Jia Chang6Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, 110 Taiwan.
Victor C Lin10Department of Urology, E-Da Hospital, Kaohsiung, 824 Taiwan.
Chao-Yuan Huang12Department of Urology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, 100 Taiwan.
I-Ling Lin14Department of Medical Laboratory Science and Biotechnology, College of Health Sciences, Kaohsiung Medical University, Kaohsiung, 807 Taiwan.
Ta-Yuan Chang15Department of Occupational Safety and Health, China Medical University, Taichung, 404 Taiwan.
Te-Ling Lu16Department of Pharmacy, China Medical University, Taichung, 404 Taiwan.
Cheng-Hsueh Lee17Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung, 807 Taiwan.
Shu-Pin Huang17Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung, 807 Taiwan.
Bo-Ying Bao16Department of Pharmacy, China Medical University, Taichung, 404 Taiwan.
China Medical University · TWKaohsiung Medical University · TWChang Gung Memorial Hospital · TWE-Da Hospital · TWKaohsiung Veterans General Hospital · TWMackay Medical College · TWNational Taiwan University Hospital · TWTaipei Medical University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo determine the association between circadian pathway genetic variants and the risk of prostate cancer progression.

methodsWe systematically evaluated 79 germline variants in nine circadian pathway genes in a cohort of 458 patients with localized prostate cancer as the discovery phase. We then replicated the significant findings in another cohort of 324 men with more advanced disease. The association of each variant with prostate cancer progression was evaluated by a log-rank test and Cox regression.

resultsA single nucleotide polymorphism of the neuronal PAS domain protein 2 (

conclusionsThe

Indexed as

Circadian rhythmNPAS2ProgressionProstate cancerSingle nucleotide polymorphism

Identifiers

PMID30996687
PMCPMC6451277
OpenAlexW2943824745

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.