ArticleJournal of materials science2018
The effect of ball mass on the mechanochemical transformation of a single-component organic system: anhydrous caffeine.
Article in Journal of materials science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed.
- The role of ball mass, surface, and contact dynamics in mechanochemical reactions.RSC mechanochemistry · 2026Article
- Anti-obesity effects of chlorogenic acid and caffeine- lipid nanoparticles through PPAR-γ/C/EBP-ɑ pathways.International journal of obesity (2005) · 2023Article
- Time-Resolved In Situ Monitoring of Mechanochemical Reactions.Angewandte Chemie (International ed. in English) · 2022Review
- A guide to direct mechanocatalysis.Chemical communications (Cambridge, England) · 2022Review
- Glycerol Valorization towards a Benzoxazine Derivative through a Milling and Microwave Sequential Strategy.Molecules (Basel, Switzerland) · 2022Article
- From amines to (form)amides: a simple and successful mechanochemical approach.Beilstein journal of organic chemistry · 2022Article
- Tribochemistry, Mechanical Alloying, Mechanochemistry: What is in a Name?Frontiers in chemistry · 2021Review
- Challenging the Ostwald rule of stages in mechanochemical cocrystallisation.Chemical science · 2020Article
- Direct Access by Mechanochemistry or Sonochemistry to Protonated Merocyanines: Components of a Four-State Molecular Switch.ChemistryOpen · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mechanochemical methodologies, particularly ball milling, have become commonplace in many laboratories. In the present work, we examine the effects of milling ball mass on the polymorphic conversion of anhydrous caffeine. By investigating a single-phase system, the rate-limiting step of particle-particle contact formation is eliminated. It is found that larger milling balls lead to considerably faster conversion rates. Modelling of the transformation rate suggests that a single, time-independent rate constant is insufficient to describe the transformation. Instead, a convolution of at least two rate-determining processes is required to correctly describe the transformation. This suggests that the early stages of the transformation are governed only by the number of particle-ball collisions. As the reaction proceeds, these collisions less frequently involve reactant, and the rate becomes limited by mass transport, or mixing, even in originally single-phase systems, which become multi-phase as the product is formed. Larger milling balls are less hindered by poorly mixed material. This likely results from a combination of higher impact energies and higher surface areas associated with the larger milling balls. Such insight is important for the selective and targeted design of mechanochemical processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.