ArticleScientific reports2019
Placental secretion of apolipoprotein A1 and E: the anti-atherogenic impact of the placenta.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 46 citations in OpenAlex.
- Systemic mRNA-LNP administration in fetuses improves survival in a mouse model of spinal muscular atrophy.Molecular therapy. Methods & clinical development · 2025Article
- Landscape of Steroid Dynamics in Pregnancy: Insights From the Maternal-Placental-Fetal Unit and Placental Models.Molecular & cellular proteomics : MCP · 2025Article
- Decreased plasma APOA1 levels are associated with increased severity of placenta accreta spectrum disorders: a nested case-control study.Frontiers in endocrinology · 2025Article
- Novel Role of Pin1-Cis P-Tau-ApoE Axis in the Pathogenesis of Preeclampsia and Its Connection with Dementia.Biomedicines · 2024Review
- Modelling the maternal-fetal interface: An in vitro approach to investigate nutrient and drug transport across the human placenta.Journal of cellular and molecular medicine · 2024Article
- Differences in HDL Remodeling during Healthy Pregnancy and Pregnancy with Cardiometabolic Complications.Antioxidants (Basel, Switzerland) · 2024Article
- A Narrative Review on the Pathophysiology of Preeclampsia.International journal of molecular sciences · 2024Review
- Circulating immune cells and apolipoprotein A mediation: a Mendelian randomization study on hypertensive disorder of pregnancy.Frontiers in immunology · 2024Article
- Obesity and Dyslipidemia: A Review of Current Evidence.Current obesity reports · 2023Review
- Characterization of lipoproteins in human placenta and fetal circulation as well as gestational changes in lipoprotein assembly and secretion in human and mouse placentas.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2023Article
- Maternal and Child Health, Non-Communicable Diseases and Metabolites.Metabolites · 2023Review
- Dissecting the Roles of Lipids in Preeclampsia.Metabolites · 2022Review
- Syncytiotrophoblast-derived extracellular vesicles carry apolipoprotein-E and affect lipid synthesis of liver cells in vitro.Journal of cellular and molecular medicine · 2022Article
- Trophoblast Differentiation Affects Crucial Nutritive Functions of Placental Membrane Transporters.Frontiers in cell and developmental biology · 2022Article
- Maternal Iron Deficiency Alters Trophoblast Differentiation and Placental Development in Rat Pregnancy.Endocrinology · 2021Article
- Upregulation of ENDOU in cytotrophoblasts from placenta complicated with preeclampsia and fetal growth restriction.Journal of clinical biochemistry and nutrition · 2021Article
- High maternal blood lipid levels during early pregnancy are associated with increased risk of congenital heart disease in offspring.Acta obstetricia et gynecologica Scandinavica · 2021Article
- Transcriptomic analysis to elucidate the effects of high stocking density on grass carp (Ctenopharyngodon idella).BMC genomics · 2021Article
- The Role of the 3Rs for Understanding and Modeling the Human Placenta.Journal of clinical medicine · 2021Review
- Screening Candidate Genes Regulating Placental Development from Trophoblast Transcriptome at Early Pregnancy in Dazu Black Goats (Animals : an open access journal from MDPI · 2021Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High levels of atherogenic lipids in pregnancy are associated with health complications for the mother, the fetus and the newborn. As endocrine secretory tissue, the human placenta releases apolipoproteins (apos), particularly apoA1 and apoE. However, the magnitude and the directionality of the apo secretions remain unknown. We aimed to 1) determine the amount and orientation (apical-maternal versus basal-fetal) of placentally secreted apoA1 and apoE using human perfused placenta and primary trophoblast cell (PTC) culture, 2) compare apoA1 and apoE secretions of PTC with that of hepatocytes and 3) associate the obtained results with human blood levels by determining apoA1 and apoE concentrations in maternal and fetal serum samples. In perfused placenta and serum samples, apoA1 and apoE concentrations were significantly higher at the maternal compared to the fetal side. For apoE a similar trend was found in PTC. For apoA1, the secretion to the apical side declined over time while release to the basal side was stable resulting in significantly different apoA1 concentrations between both sides. Unexpectedly, PTC secreted significantly higher amounts of apoA1 and apoE compared to hepatocytes. Our data indicate that the placenta may play an important role in maternal and fetal cholesterol homeostasis via secretion of anti-atherogenic apos.
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