ArticleScientific reports2019
Slowing less than 1 Hz is decreased near the seizure onset zone.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Probabilistic comparison of gray and white matter coverage between depth and surface intracranial electrodes in epilepsy.Scientific reports · 2021Trial
- Paroxysmal slow waves mark ictal networks.Epilepsia · 2026Article
- Integrating data across oscillatory power bands predicts the seizure onset zone in focal epilepsies.Brain communications · 2026Article
- Adaptation modulates effective connectivity and network stability.Frontiers in computational neuroscience · 2026Article
- Direct intracranial EEG evidence for a local breakdown in normal sleep homeostasis at the human seizure onset zone.medRxiv : the preprint server for health sciences · 2025Article
- EEG focal delta slowing in focal epilepsy - A didactic review.Clinical neurophysiology practice · 2025Review
- Binaural beats at 0.25 Hz shorten the latency to slow-wave sleep during daytime naps.Scientific reports · 2024Article
- Lateralization of delta band power in magnetoencephalography (MEG) in patients with unilateral focal epilepsy and its relation to verbal fluency.Brain and behavior · 2023Article
- Molecular changes underlying decay of sensory responses and enhanced seizure propensity in peritumoral neurons.Neuro-oncology · 2023Article
- Dynamics of AMPA receptors regulate epileptogenesis in patients with epilepsy.Cell reports. Medicine · 2023Article
- Deep learning-based automated detection and multiclass classification of focal interictal epileptiform discharges in scalp electroencephalograms.Scientific reports · 2023Article
- Neural adaptation and fractional dynamics as a window to underlying neural excitability.PLoS computational biology · 2023Article
- Distinct signatures of loss of consciousness in focal impaired awareness versus tonic-clonic seizures.Brain : a journal of neurology · 2023Article
- Diagnosis of Epilepsy with Functional Connectivity in EEG after a Suspected First Seizure.Bioengineering (Basel, Switzerland) · 2022Article
- E.L., a modern-day Phineas Gage: Revisiting frontal lobe injury.Lancet regional health. Americas · 2022Article
- Normative intracranial EEG maps epileptogenic tissues in focal epilepsy.Brain : a journal of neurology · 2022Article
- Case Report: Prolonged Effects of Short-Term Transcranial Magnetic Stimulation on EEG Biomarkers, Spectral Power, and Seizure Frequency.Frontiers in neuroscience · 2022Article
- Neuronal excitatory-to-inhibitory balance is altered in cerebral organoid models of genetic neurological diseases.Molecular brain · 2021Article
- Exacerbation of Epilepsy by Astrocyte Alkalization and Gap Junction Uncoupling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- The Menstrual Cycle Alters Resting-State Cortical Activity: A Magnetoencephalography Study.Frontiers in human neuroscience · 2021Article
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Authors and funding
5 authors.
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Abstract
Focal slowing (<4 Hz) of brain waves is often associated with focal cerebral dysfunction and is assumed to be increased closest to the location of dysfunction. Prior work suggests that slowing may be comprised of at least two distinct neural mechanisms: slow oscillation activity (<1 Hz) may reflect primarily inhibitory cortical mechanisms while power in the delta frequency (1-4 Hz) may correlate with local synaptic strength. In focal epilepsy patients, we examined slow wave activity near and far from the seizure onset zone (SOZ) during wake, sleep, and postictal states using intracranial electroencephalography. We found that slow oscillation (0.3-1 Hz) activity was decreased near the SOZ, while delta activity (2-4 Hz) activity was increased. This finding was most prominent during sleep, and accompanied by a loss of long-range intra-hemispheric synchrony. In contrast to sleep, postictal slowing was characterized by a broadband increase of spectral power, and showed a reduced modulatory effect of slow oscillations on higher frequencies. These results suggest slow oscillation focal slowing is reduced near the seizure onset zone, perhaps reflecting reduced inhibitory activity. Dissociation between slow oscillation and delta slowing could help localize the seizure onset zone from interictal intracranial recordings.
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